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  3. RPTOR

RPTOR (Regulatory associated protein of MTOR complex 1)

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Summary of RPTOR

The gene codes for a protein, regulatory associated protein of MTOR complex 1. It is a part of the signaling pathway which regulates cell growth in response to nutrient and insulin levels [R].

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The Function of RPTOR

Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis.

Protein names

Recommended name:

Regulatory-associated protein of mTOR

Alternative name(s):

Raptor
p150 target of rapamycin (TOR

RPTOR SNPs

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  1. RS12940622 (RPTOR) ??
  2. RS2672886 (RPTOR) ??
  3. RS28587833 (RPTOR) ??
  4. RS7215564 (RPTOR) ??
  5. RS7503807 (RPTOR) ??
  6. RS8066384 (RPTOR) ??

Top Gene-Substance Interactions

RPTOR Interacts with These Diseases

Disease Score

Substances That Increase RPTOR

Substances Interaction Organism Category

Substances That Decrease RPTOR

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

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