Summary of RPS26
The gene codes for a protein, ribosomal protein S26. The gene codes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. It is found in the cytoplasm [R].
Protein names
Recommended name:
40S ribosomal protein S26- RS11171739 (RPS26) ??
- RS1131017 (RPS26) ??
- RS12580100 (RPS26) ??
- RS7312770 (RPS26) ??
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Top Gene-Substance Interactions
Substances That Increase RPS26
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Substances That Decrease RPS26
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Advanced Summary
Diamond-Blackfan anemia At least nine RPS26 gene mutations have been identified in individuals with Diamond-Blackfan anemia. These mutations are believed to affect the stability or function of the RPS26 protein. Studies indicate that a shortage of functioning ribosomal proteins may increase the self-destruction of blood-forming cells in the bone marrow, resulting in a low number of red blood cells (anemia). Abnormal regulation of cell division or inappropriate triggering of apoptosis may contribute to the other health problems and unusual physical features that affect some people with Diamond-Blackfan anemia.
The RPS26 gene provides instructions for making one of approximately 80 different ribosomal proteins, which are components of cellular structures called ribosomes. Ribosomes process the cell's genetic instructions to create proteins. Each ribosome is made up of two parts (subunits) called the large and small subunits. The protein produced from the RPS26 gene is among those found in the small subunit. The specific functions of the RPS26 protein and the other ribosomal proteins within these subunits are unclear. Some ribosomal proteins are involved in the assembly or stability of ribosomes. Others help carry out the ribosome's main function of building new proteins. Studies suggest that some ribosomal proteins may have other functions, such as participating in chemical signaling pathways within the cell, regulating cell division, and controlling the self-destruction of cells (apoptosis).
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Mrna Binding
- Structural Constituent Of Ribosome
- Poly(A) Rna Binding
- Cadherin Binding Involved In Cell-Cell Adhesion
Biological Processes:
- Nuclear-Transcribed Mrna Catabolic Process, Nonsense-Mediated Decay
- Rrna Processing
- Translation
- Translational Initiation
- Srp-Dependent Cotranslational Protein Targeting To Membrane
- Viral Transcription
- Negative Regulation Of Rna Splicing