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  3. RPS26

RPS26 (Ribosomal protein S26)

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Summary of RPS26

The gene codes for a protein, ribosomal protein S26. The gene codes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. It is found in the cytoplasm [R].

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Protein names

Recommended name:

40S ribosomal protein S26

RPS26 SNPs

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  1. RS11171739 (RPS26) ??
  2. RS1131017 (RPS26) ??
  3. RS12580100 (RPS26) ??
  4. RS7312770 (RPS26) ??

Top Gene-Substance Interactions

Substances That Increase RPS26

Substances Interaction Organism Category

Substances That Decrease RPS26

Substances Interaction Organism Category

Advanced Summary

     Diamond-Blackfan anemia At least nine RPS26 gene mutations have been identified in individuals with Diamond-Blackfan anemia. These mutations are believed to affect the stability or function of the RPS26 protein. Studies indicate that a shortage of functioning ribosomal proteins may increase the self-destruction of blood-forming cells in the bone marrow, resulting in a low number of red blood cells (anemia). Abnormal regulation of cell division or inappropriate triggering of apoptosis may contribute to the other health problems and unusual physical features that affect some people with Diamond-Blackfan anemia.

     The RPS26 gene provides instructions for making one of approximately 80 different ribosomal proteins, which are components of cellular structures called ribosomes. Ribosomes process the cell's genetic instructions to create proteins. Each ribosome is made up of two parts (subunits) called the large and small subunits. The protein produced from the RPS26 gene is among those found in the small subunit. The specific functions of the RPS26 protein and the other ribosomal proteins within these subunits are unclear. Some ribosomal proteins are involved in the assembly or stability of ribosomes. Others help carry out the ribosome's main function of building new proteins. Studies suggest that some ribosomal proteins may have other functions, such as participating in chemical signaling pathways within the cell, regulating cell division, and controlling the self-destruction of cells (apoptosis).

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • RORalpha2
  • HNF-4alpha1
  • HNF-4alpha2
  • XBP-1
  • ATF6

Gene Pathways:

  • Disease
  • Metabolism of proteins
  • Gene Expression
  • Metabolism of RNA
  • 3' -UTR-mediated translational regulation
  • Ribosome

Molecular Function:

  • Cadherin Binding Involved In Cell-Cell Adhesion
  • Mrna Binding
  • Poly(A) Rna Binding
  • Structural Constituent Of Ribosome

Biological Processes:

  • Negative Regulation Of Rna Splicing
  • Nuclear-Transcribed Mrna Catabolic Process, Nonsense-Mediated Decay
  • Rrna Processing
  • Srp-Dependent Cotranslational Protein Targeting To Membrane
  • Translation
  • Translational Initiation
  • Viral Transcription
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 40S ribosomal protein S26| 40S ribosomal protein S26-like protein| anon-EST:fe2A3| anon-fast-evolving-2A3| CB1_000449017| CG10305 gene product from transcript CG10305-RE| CG10305-PA| CG10305-PB| CG10305-PC| CG10305-PD| CG10305-PE| D623_10009164| DBA10| Dmel_CG10305| GW7_15770| M(2)36F| M(2)m| M(2)S13| M91_07253| minute (2) 36F| M[[s]]| N308_02369| N325_01319| OVRPS26| PAL_GLEAN10004809| PANDA_004073| putative ribosomal protein S26 variant 1| ribosomal protein S31| RpS26-PA| RpS26-PB| RpS26-PC| RpS26-PD| RpS26-PE| rpS31| S26| Y1Q_007581| Zinc finger protein Eos| rps26

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