The Function of RPN2
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.
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Protein names
Recommended name:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2Short name:
RIBIIRAlternative name(s):
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunitRibophorin II
RPN-II
Ribophorin-2
- RS6031882 (RPN2) ??
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Top Gene-Substance Interactions
RPN2 Interacts with These Diseases
| Disease | Score |
Substances That Increase RPN2
| Substances | Interaction | Organism | Category |
Substances That Decrease RPN2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in all tissues tested.
Gene Pathways:
Molecular Function:
Biological Processes:
- Cellular Protein Modification Process
- Protein N-Linked Glycosylation
- Aging
- Protein N-Linked Glycosylation Via Asparagine