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  3. RPN2

RPN2 (Ribophorin II)

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The Function of RPN2

Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains.

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Protein names

Recommended name:

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

Short name:

RIBIIR

Alternative name(s):

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit
Ribophorin II
RPN-II
Ribophorin-2

RPN2 SNPs

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  1. RS6031882 (RPN2) ??

Top Gene-Substance Interactions

RPN2 Interacts with These Diseases

Disease Score

Substances That Increase RPN2

Substances Interaction Organism Category

Substances That Decrease RPN2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • MEF-2A
  • NF-E2
  • NF-E2 p45
  • AP-2gamma
  • Gfi-1
  • AP-2beta

Tissue specificity:

Expressed in all tissues tested.

Gene Pathways:

  • Metabolic pathways
  • Metabolism of proteins
  • Gene Expression
  • N-Glycan biosynthesis
  • Proteasome
  • Protein processing in endoplasmic reticulum

Molecular Function:

  • Ribosome Binding
  • Transferase Activity, Transferring Glycosyl Groups

Biological Processes:

  • Aging
  • Cellular Protein Modification Process
  • Protein N-Linked Glycosylation
  • Protein N-Linked Glycosylation Via Asparagine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| p110| S1| oligosaccharyltransferase complex subunit (non-catalytic)| 11888| 26S proteasome non-ATPase regulatory subunit 1| A306_00295| AS27_09726| AS28_13701| AV261018| CB1_001108058| CG11888 gene product from transcript CG11888-RC| CG11888-PA| CG11888-PB| CG11888-PC| D623_10009343| Dmel_CG11888| dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit| Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 65-II kDa subunit| Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2| dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit 2-like protein| dRpn2| fb95d11| fj62b10| I79_002617| M91_02811| M959_06616| MDA_GLEAN10022720| N300_03281| N301_08032| N302_00201| N303_13169| N305_03185| N306_02702| N307_07049| N308_10724| N309_09797| N310_03935| N311_10034| N312_05891| N320_03408| N321_06616| N322_01733| N324_04897| N326_11964| N327_10455| N328_10051| N329_10794| N330_11121| N331_07393| N332_10559| N333_03018| N334_11853| N335_06636| N336_01358| N339_10742| N340_10987| N341_08226| PANDA_003175| PSMC1| regulatory particle non-ATPase 2| RIBIIR| Ribophorin-2| Rpn-2| Rpn2-PA| Rpn2-PB| Rpn2-PC| RPNII| RPN-II| SWP1| TREES_T100008658| UY3_04590| Y1Q_003600| Y956_12322| Z169_03754| rpn2

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