The Function of RNF115
E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.
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Protein names
Recommended name:
E3 ubiquitin-protein ligase RNF115Alternative name(s):
RING finger protein 115Rabring 7
Zinc finger protein 364
- RS12744221 (RNF115) ??
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Top Gene-Substance Interactions
Substances That Increase RNF115
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Substances That Decrease RNF115
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells.
Molecular Function:
- Ubiquitin-Protein Transferase Activity
- Zinc Ion Binding
- Ligase Activity
- Ubiquitin Protein Ligase Activity
Biological Processes:
- Protein Polyubiquitination
- Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
- Protein Ubiquitination Involved In Ubiquitin-Dependent Protein Catabolic Process
- Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
- Ubiquitin-Dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
- Protein Autoubiquitination
- Protein K63-Linked Ubiquitination
- Protein K48-Linked Ubiquitination