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  3. RNF115

RNF115 (Ring finger protein 115)

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The Function of RNF115

E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.

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Protein names

Recommended name:

E3 ubiquitin-protein ligase RNF115

Alternative name(s):

RING finger protein 115
Rabring 7
Zinc finger protein 364

RNF115 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12744221 (RNF115) ??

Top Gene-Substance Interactions

Substances That Increase RNF115

Substances Interaction Organism Category

Substances That Decrease RNF115

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • FOXO3
  • FOXO3a
  • Nkx2-5
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b
  • E47
  • Hand1
  • LCR-F1

Tissue specificity:

Expressed at extremely low levels in normal breast, prostate, lung, colon. Higher levels of expression are detected in heart, skeletal muscle, testis as well as in breast and prostate cancer cells.

Molecular Function:

  • Ligase Activity
  • Ubiquitin Protein Ligase Activity
  • Ubiquitin-Protein Transferase Activity
  • Zinc Ion Binding

Biological Processes:

  • Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
  • Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
  • Protein Autoubiquitination
  • Protein K48-Linked Ubiquitination
  • Protein K63-Linked Ubiquitination
  • Protein Polyubiquitination
  • Protein Ubiquitination Involved In Ubiquitin-Dependent Protein Catabolic Process
  • Ubiquitin-Dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_17730| AS27_10368| AS28_00775| BCA2| CB1_000061017| E3 ubiquitin-protein ligase RNF115| E3 ubiquitin-protein ligase RNF115-like| EGK_01173| EH28_10427| GW7_07968| H920_07573| I79_004487| M959_14612| N300_10911| N301_02539| N303_12598| N306_08441| N308_02593| N312_03218| N321_10476| N322_07005| N325_09348| N326_04926| N327_02023| N328_05257| N329_04547| N331_05540| N333_05473| N335_06565| PAL_GLEAN10017497| PANDA_013977| Rab7-interacting RING finger protein| Rabring7| Rabring 7| RING finger protein 115-like protein| UY3_11529| Y1Q_003983| Y956_08228| Z169_08696| Zfp364| zinc finger protein 364| Zinc finger protein 364-like protein| ZNF364| rnf115

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