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  3. RLIM

RLIM (Ring finger protein, LIM domain interacting)

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Summary of RLIM

The gene codes for a protein, ring finger protein, LIM domain interacting. The protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor [R].

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The Function of RLIM

E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.

Protein names

Recommended name:

E3 ubiquitin-protein ligase RLIM

Short name:

R-LIM

Alternative name(s):

LIM domain-interacting RING finger protein
RING finger LIM domain-binding protein
RING finger protein 12
Renal carcinoma antigen NY-REN-43

RLIM SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1391511 (RLIM) ??

Top Gene-Substance Interactions

RLIM Interacts with These Diseases

Disease Score

Substances That Increase RLIM

Substances Interaction Organism Category

Substances That Decrease RLIM

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • c-Myc

Tissue specificity:

Expressed in many tissues.

Molecular Function:

  • Ligase Activity
  • Transcription Corepressor Activity
  • Ubiquitin Protein Ligase Activity
  • Ubiquitin-Protein Transferase Activity
  • Zinc Ion Binding

Biological Processes:

  • Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Negative Regulation Of Transcription, Dna-Templated
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
  • Protein Polyubiquitination
  • Protein Ubiquitination
  • Random Inactivation Of X Chromosome
  • Regulation Of Dosage Compensation By Inactivation Of X Chromosome
  • Regulation Of Transcription, Dna-Templated
  • Transcription, Dna-Templated
  • Ubiquitin-Dependent Protein Catabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AL022832| Anapl_10795| AS27_04402| AS28_12333| CB1_000523001| D623_10003062| E3 ubiquitin-protein ligase RLIM| E3 ubiquitin-protein ligase RNF12| E3 ubiquitin-protein ligase RNF12-A| H920_00794| Ha1r| Hoxa1 regulated| LIM domain interacting RING finger protein| LIM domain-interacting RING finger protein| M959_10343| MDA_GLEAN10001455| MRX61| N300_11341| N301_11854| N302_09437| N303_07831| N305_11969| N306_06753| N307_10199| N308_04726| N309_04503| N310_04079| N311_05850| N312_11263| N321_09669| N322_05172| N324_02189| N326_13305| N327_06208| N328_07955| N329_12365| N330_05896| N332_05622| N333_04458| N334_10319| N335_05194| N336_06194| N340_12474| ny-ren-43| PAL_GLEAN10001169| PANDA_019274| renal carcinoma antigen NY-REN-43| RING finger LIM domain-binding protein| ring finger protein 12| ring zinc finger LIM domain binding protein| ring zinc finger protein NY-REN-43antigen| R-LIM| Rlim1| rlim-a| rlim-b| RNF12| rnf12b| TREES_T100005847| UY3_07415| XRnf12| Y1Q_000775| Y956_12194| Z169_13395| rlim

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