Summary of RLIM
The gene codes for a protein, ring finger protein, LIM domain interacting. The protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor [R].
The Function of RLIM
E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
Protein names
Recommended name:
E3 ubiquitin-protein ligase RLIMShort name:
R-LIMAlternative name(s):
LIM domain-interacting RING finger proteinRING finger LIM domain-binding protein
RING finger protein 12
Renal carcinoma antigen NY-REN-43
- RS1391511 (RLIM) ??
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Top Gene-Substance Interactions
RLIM Interacts with These Diseases
| Disease | Score |
Substances That Increase RLIM
| Substances | Interaction | Organism | Category |
Substances That Decrease RLIM
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in many tissues.
Molecular Function:
- Transcription Corepressor Activity
- Ubiquitin-Protein Transferase Activity
- Zinc Ion Binding
- Ligase Activity
- Ubiquitin Protein Ligase Activity
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Protein Polyubiquitination
- Transcription, Dna-Templated
- Regulation Of Transcription, Dna-Templated
- Ubiquitin-Dependent Protein Catabolic Process
- Protein Ubiquitination
- Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Negative Regulation Of Transcription, Dna-Templated
- Random Inactivation Of X Chromosome
- Regulation Of Dosage Compensation By Inactivation Of X Chromosome