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  3. RIPK3

RIPK3 (Receptor interacting serine/threonine kinase 3)

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The Function of RIPK3

Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.

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Protein names

Recommended name:

Receptor-interacting serine/threonine-protein kinase 3

Short name:

RIP-3

Alternative name(s):

RIP-like protein kinase 3
Receptor-interacting protein 3

RIPK3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1950500 (RIPK3) ??

Top Gene-Substance Interactions

Substances That Increase RIPK3

Substances Interaction Organism Category

Substances That Decrease RIPK3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • STAT3
  • NF-kappaB1
  • HNF-4alpha1
  • HNF-4alpha2
  • IRF-1
  • STAT1
  • STAT1beta
  • STAT1alpha
  • AML1a

Tissue specificity:

Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.

Gene Pathways:

  • Immune System
  • Cytosolic DNA-sensing pathway

Molecular Function:

  • Atp Binding
  • Identical Protein Binding
  • Nf-Kappab-Inducing Kinase Activity
  • Protein Complex Binding
  • Protein Serine/Threonine Kinase Activity
  • Transcription Coactivator Activity

Biological Processes:

  • Activation Of Protein Kinase Activity
  • Amyloid Fibril Formation
  • Apoptotic Signaling Pathway
  • Cellular Protein Modification Process
  • I-Kappab Kinase/Nf-Kappab Signaling
  • Lymph Node Development
  • Necroptotic Process
  • Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
  • Positive Regulation Of Ligase Activity
  • Positive Regulation Of Necroptotic Process
  • Positive Regulation Of Nf-Kappab Transcription Factor Activity
  • Positive Regulation Of Oxidoreductase Activity
  • Positive Regulation Of Phosphatase Activity
  • Positive Regulation Of Protein Deacetylation
  • Positive Regulation Of Reactive Oxygen Species Metabolic Process
  • Protein Autophosphorylation
  • Protein Heterooligomerization
  • Protein Homooligomerization
  • Regulation Of Activated T Cell Proliferation
  • Regulation Of Activation-Induced Cell Death Of T Cells
  • Regulation Of Adaptive Immune Response
  • Regulation Of Cd8-Positive, Alpha-Beta Cytotoxic T Cell Extravasation
  • Regulation Of Interferon-Gamma Production
  • Regulation Of T Cell Mediated Cytotoxicity
  • Signal Transduction
  • Spleen Development
  • T Cell Differentiation In Thymus
  • T Cell Homeostasis
  • Thymus Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| RIP3| D623_10003694| Hcyp2| homocysteine respondent protein HCYP2| I79_008528| M91_13220| mRIP3| PAL_GLEAN10002500| receptor interacting protein 3| receptor-interacting protein 3| receptor-interacting serine-threonine kinase 2-like| receptor-interacting serine-threonine kinase 3| receptor-interacting serine-threonine kinase 3 like| receptor-interacting serine/threonine-protein kinase 3| receptor-interacting serine/threonine-protein kinase 3-like protein| RIP-3| ripk3l| RIP-like protein kinase 3| Y1Q_022345| ripk3

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