The Function of RIPK3
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
Protein names
Recommended name:
Receptor-interacting serine/threonine-protein kinase 3Short name:
RIP-3Alternative name(s):
RIP-like protein kinase 3Receptor-interacting protein 3
- RS1950500 (RIPK3) ??
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Top Gene-Substance Interactions
Substances That Increase RIPK3
| Substances | Interaction | Organism | Category |
Substances That Decrease RIPK3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in the pancreas. Detected at lower levels in heart, placenta, lung and kidney. Isoform 3 is significantly increased in colon and lung cancers.
Gene Pathways:
Molecular Function:
- Transcription Coactivator Activity
- Protein Serine/Threonine Kinase Activity
- Nf-Kappab-Inducing Kinase Activity
- Atp Binding
- Protein Complex Binding
- Identical Protein Binding
Biological Processes:
- Regulation Of T Cell Mediated Cytotoxicity
- Regulation Of Adaptive Immune Response
- Cellular Protein Modification Process
- Signal Transduction
- I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of Phosphatase Activity
- Activation Of Protein Kinase Activity
- Regulation Of Interferon-Gamma Production
- T Cell Differentiation In Thymus
- T Cell Homeostasis
- Regulation Of Activated T Cell Proliferation
- Protein Autophosphorylation
- Lymph Node Development
- Spleen Development
- Thymus Development
- Positive Regulation Of Nf-Kappab Transcription Factor Activity
- Protein Homooligomerization
- Protein Heterooligomerization
- Positive Regulation Of Ligase Activity
- Positive Regulation Of Oxidoreductase Activity
- Positive Regulation Of Necroptotic Process
- Regulation Of Activation-Induced Cell Death Of T Cells
- Necroptotic Process
- Positive Regulation Of Protein Deacetylation
- Apoptotic Signaling Pathway
- Amyloid Fibril Formation
- Positive Regulation Of Reactive Oxygen Species Metabolic Process
- Regulation Of Cd8-Positive, Alpha-Beta Cytotoxic T Cell Extravasation
- Positive Regulation Of Intrinsic Apoptotic Signaling Pathway