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  3. RIMS1

RIMS1 (Regulating synaptic membrane exocytosis 1)

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The Function of RIMS1

Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

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Protein names

Recommended name:

Regulating synaptic membrane exocytosis protein 1

Short name:

RIM 1

Alternative name(s):

Rab-3-interacting molecule 1
Rab-3-interacting protein 2

RIMS1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10455248 (RIMS1) ??
  2. RS1334346 (RIMS1) ??
  3. RS1339227 (RIMS1) ??
  4. RS2249625 (RIMS1) ??
  5. RS4707930 (RIMS1) ??

Top Gene-Substance Interactions

Substances That Increase RIMS1

Substances Interaction Organism Category

Substances That Decrease RIMS1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • MEF-2A
  • MRF-2
  • GATA-1
  • p300

Tissue specificity:

Expressed in melanocytes (PubMed:23999003). Detected in brain and retina (PubMed:23999003).

Gene Pathways:

  • Neuronal System

Molecular Function:

  • Gtpase Regulator Activity
  • Ion Channel Binding
  • Metal Ion Binding
  • Poly(A) Rna Binding
  • Rab Gtpase Binding

Biological Processes:

  • Calcium Ion Regulated Exocytosis
  • Calcium Ion-Regulated Exocytosis Of Neurotransmitter
  • Glutamate Secretion
  • Intracellular Protein Transport
  • Membrane Fusion
  • Neurotransmitter Secretion
  • Positive Regulation Of Dendrite Extension
  • Positive Regulation Of Excitatory Postsynaptic Potential
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Inhibitory Postsynaptic Potential
  • Protein Complex Assembly
  • Regulated Exocytosis
  • Regulation Of Membrane Potential
  • Regulation Of Neurotransmitter Secretion
  • Regulation Of Synaptic Vesicle Exocytosis
  • Response To Stimulus
  • Secretion
  • Synaptic Vesicle Exocytosis
  • Visual Perception
  • Long-Term Synaptic Potentiation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| RIM| A306_00613| AS27_06832| AS28_12120| CB1_001499006| CORD7| D623_10025821| H920_02475| I79_001303| M959_03111| MDA_GLEAN10020509| N300_07828| N301_05802| N302_02537| N303_02299| N305_14209| N306_10885| N308_03543| N309_11191| N310_12389| N322_09818| N325_08800| N328_10635| N330_13609| N341_06959| PAL_GLEAN10025259| PANDA_004718| Rab3 effector| rab-3-interacting molecule 1| rab3-interacting molecule 1| rab-3-interacting protein 1| rab3-interacting protein 1| Rab3 interacting protein 1| rab-3-interacting protein 2| RAB3-interacting protein 2| Rab3ip1| RAB3IP2| rabsip2| regulating synaptic membrane exocytosis 1 beta| regulating synaptic membrane exocytosis 2| Regulating synaptic membrane exocytosis protein 1| Regulating synaptic membrane exocytosis protein 2| regulating synaptic membrane exocytosis protein 2-like protein| RIM1| RIM 1| RIM1a| RIM1alpha| Rim1b protein| RIMS2| Serg1| synaptic exocytosis regulator 1| UY3_08652| Y1Q_015344| Y956_07921| Z169_13143| rims1

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