The Function of RIMS1
Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
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Protein names
Recommended name:
Regulating synaptic membrane exocytosis protein 1Short name:
RIM 1Alternative name(s):
Rab-3-interacting molecule 1Rab-3-interacting protein 2
- RS10455248 (RIMS1) ??
- RS1334346 (RIMS1) ??
- RS1339227 (RIMS1) ??
- RS2249625 (RIMS1) ??
- RS4707930 (RIMS1) ??
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Top Gene-Substance Interactions
Substances That Increase RIMS1
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Substances That Decrease RIMS1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in melanocytes (PubMed:23999003). Detected in brain and retina (PubMed:23999003).
Gene Pathways:
Molecular Function:
- Gtpase Regulator Activity
- Ion Channel Binding
- Metal Ion Binding
- Poly(A) Rna Binding
- Rab Gtpase Binding
Biological Processes:
- Calcium Ion Regulated Exocytosis
- Calcium Ion-Regulated Exocytosis Of Neurotransmitter
- Glutamate Secretion
- Intracellular Protein Transport
- Membrane Fusion
- Neurotransmitter Secretion
- Positive Regulation Of Dendrite Extension
- Positive Regulation Of Excitatory Postsynaptic Potential
- Positive Regulation Of Gene Expression
- Positive Regulation Of Inhibitory Postsynaptic Potential
- Protein Complex Assembly
- Regulated Exocytosis
- Regulation Of Membrane Potential
- Regulation Of Neurotransmitter Secretion
- Regulation Of Synaptic Vesicle Exocytosis
- Response To Stimulus
- Secretion
- Synaptic Vesicle Exocytosis
- Visual Perception
- Long-Term Synaptic Potentiation