The Function of RIMS1
Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
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Protein names
Recommended name:
Regulating synaptic membrane exocytosis protein 1Short name:
RIM 1Alternative name(s):
Rab-3-interacting molecule 1Rab-3-interacting protein 2
- RS10455248 (RIMS1) ??
- RS1334346 (RIMS1) ??
- RS1339227 (RIMS1) ??
- RS2249625 (RIMS1) ??
- RS4707930 (RIMS1) ??
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Top Gene-Substance Interactions
Substances That Increase RIMS1
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Substances That Decrease RIMS1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in melanocytes (PubMed:23999003). Detected in brain and retina (PubMed:23999003).
Gene Pathways:
Molecular Function:
- Rab Gtpase Binding
- Gtpase Regulator Activity
- Ion Channel Binding
- Poly(A) Rna Binding
- Metal Ion Binding
Biological Processes:
- Protein Complex Assembly
- Intracellular Protein Transport
- Neurotransmitter Secretion
- Visual Perception
- Positive Regulation Of Gene Expression
- Glutamate Secretion
- Synaptic Vesicle Exocytosis
- Calcium Ion Regulated Exocytosis
- Regulation Of Membrane Potential
- Regulated Exocytosis
- Secretion
- Regulation Of Neurotransmitter Secretion
- Calcium Ion-Regulated Exocytosis Of Neurotransmitter
- Response To Stimulus
- Long-Term Synaptic Potentiation
- Membrane Fusion
- Positive Regulation Of Inhibitory Postsynaptic Potential
- Positive Regulation Of Dendrite Extension
- Regulation Of Synaptic Vesicle Exocytosis
- Positive Regulation Of Excitatory Postsynaptic Potential