The Function of RHOB
Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.
Protein names
Recommended name:
Rho-related GTP-binding protein RhoBAlternative name(s):
Rho cDNA clone 6h6
- RS13021401 (RHOB) ??
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Top Gene-Substance Interactions
RHOB Interacts with These Diseases
| Disease | Score |
Substances That Increase RHOB
| Substances | Interaction | Organism | Category |
Substances That Decrease RHOB
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
Up-regulated by DNA damaging agents like H(2)O(2) or ionizing radiation (IR).
Molecular Function:
Biological Processes:
- Angiogenesis
- Apoptotic Process
- Cell Adhesion
- Cell Differentiation
- Cellular Response To Hydrogen Peroxide
- Cellular Response To Ionizing Radiation
- Cytokinesis
- Endosome To Lysosome Transport
- Endothelial Tube Morphogenesis
- Intracellular Protein Transport
- Negative Regulation Of Cell Cycle
- Negative Regulation Of Cell Migration
- Platelet Activation
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Endothelial Cell Migration
- Regulation Of Cell Migration
- Regulation Of Small Gtpase Mediated Signal Transduction
- Rho Protein Signal Transduction
Drug Bank:
- Botulinum Toxin Type A