From NCBI Gene: Essential hypertension

     From NCBI Gene: This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011] From UniProt: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

The following transcription factors affect gene expression:

• p53

Molecular Function:

• Gtpase Activator Activity

Biological Processes:

• Negative Regulation Of Signal Transduction
• Regulation Of G-Protein Coupled Receptor Protein Signaling Pathway