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  3. RGS5

RGS5 (Regulator of G-protein signaling 5)

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Summary of RGS5

The gene codes for a protein, regulator of G-protein signaling 5. It is linked to elevated blood pressure [R].

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The Function of RGS5

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

Protein names

Recommended name:

Regulator of G-protein signaling 5

Short name:

RGS5

RGS5 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10917696 (RGS5) ??
  2. RS12035879 (RGS5) ??
  3. RS1507740 (RGS5) ??
  4. RS2063142 (RGS5) ??
  5. RS2662776 (RGS5) ??

Top Gene-Substance Interactions

Substances That Increase RGS5

Substances Interaction Organism Category

Substances That Decrease RGS5

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Essential hypertension

     From NCBI Gene: This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011] From UniProt: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53

Molecular Function:

  • Gtpase Activator Activity

Biological Processes:

  • Negative Regulation Of Signal Transduction
  • Regulation Of G-Protein Coupled Receptor Protein Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_00354| AS28_09886| GW7_18060| H920_04152| I79_013101| M91_04383| M959_05851| MST092| MST106| MST129| MSTP032| MSTP092| MSTP106| MSTP129| N300_02691| N301_09617| N302_00559| N303_03599| N305_11288| N306_01440| N307_11702| N308_05743| N310_02453| N311_06188| N312_08450| N320_09266| N321_08299| N322_04248| N324_09241| N326_05070| N329_00444| N332_00865| N333_06118| N334_11076| N335_08113| N336_05478| N339_11813| N340_02044| PAL_GLEAN10017904| PANDA_008838| regulator of G-protein signaling 5-like protein| regulator of G-protein signalling 5| TREES_T100015706| UY3_03711| XELAEV_18023405mg| xrgs5| Y1Q_029557| Y956_03493| Z169_13506| rgs5

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