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  3. RGS4

RGS4 (Regulator of G-protein signaling 4)

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Summary of RGS4

The gene codes for a protein, regulator of G-protein signaling 4. The protein negatively regulates signaling at the level of the heterotrimeric G protein and is found in the cytoplasm [R].

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The Function of RGS4

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

Protein names

Recommended name:

Regulator of G-protein signaling 4

Short name:

RGP4

Alternative name(s):

RGS4

RGS4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10759 (RGS4) ??
  2. RS1507740 (RGS4) ??
  3. RS2063142 (RGS4) ??
  4. RS2661319 (RGS4) ??
  5. RS2842030 (RGS4) ??

Top Gene-Substance Interactions

RGS4 Interacts with These Diseases

Disease Score

Substances That Increase RGS4

Substances Interaction Organism Category

Substances That Decrease RGS4

Substances Interaction Organism Category

Advanced Summary

     From UniProt: Schizophrenia 9 (SCZD9): A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. [MIM:604906]

     From NCBI Gene: Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] From UniProt: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • deltaCREB

Tissue specificity:

Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum.

Molecular Function:

  • Calmodulin Binding
  • Gtpase Activator Activity

Biological Processes:

  • Inactivation Of Mapk Activity
  • Negative Regulation Of G-Protein Coupled Receptor Protein Signaling Pathway
  • Regulation Of G-Protein Coupled Receptor Protein Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| SCZD9| A306_13453| AS27_00353| AS28_09885| CB1_000087001| D623_10024295| EGK_21224| ESTM48| ESTM50| G-protein signaling 4 regulator| GW7_18061| H920_04151| I79_013102| M959_05852| N300_02690| N301_09616| N302_00560| N303_03600| N305_11289| N306_01441| N307_11701| N308_05744| N309_13914| N310_02454| N311_06187| N312_01105| N320_12941| N321_08298| N322_04247| N324_09240| N325_09659| N326_10685| N327_07790| N328_09656| N330_04384| N332_00864| N333_06117| N334_09517| N335_11631| N336_05479| N339_11814| N340_02045| N341_08804| PANDA_008839| regulator of G-protein signaling 4-like protein| regulator of G-protein signalling 4| rgp4| schizophrenia disorder 9| TREES_T100015727| UY3_03712| XRgs4| XRgs4a| Y1Q_022854| Y956_03494| Z169_13507| rgs4

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