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  3. RETN

RETN (Resistin)

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Summary of RETN

The gene codes for a protein, resistin. The hormone is links obesity to type II diabetes [R].

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The Function of RETN

Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.

Protein names

Recommended name:

Resistin

Short name:

ADSF

Alternative name(s):

Adipose tissue-specific secretory factor
C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein
Cysteine-rich secreted protein A12-alpha-like 2
Cysteine-rich secreted protein FIZZ3

RETN SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1423096 (RETN) ??
  2. RS1862513 (RETN) ??
  3. RS3219175 (RETN) ??
  4. RS3745367 (RETN) ??
  5. RS3745369 (RETN) ??

Top Gene-Substance Interactions

RETN Interacts with These Diseases

Disease Score

Substances That Increase RETN

Substances Interaction Organism Category

Substances That Decrease RETN

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Diabetes mellitus type 2

     From NCBI Gene: This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010] From UniProt: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • NF-kappaB1
  • PPAR-alpha
  • C/EBPalpha
  • SREBP-1a
  • SREBP-1c
  • SREBP-1b
  • p300

Tissue specificity:

Expressed only in fatty tissues.

Molecular Function:

  • Hormone Activity

Biological Processes:

  • Aging
  • Fat Cell Differentiation
  • Negative Regulation Of Feeding Behavior
  • Positive Regulation Of Collagen Metabolic Process
  • Positive Regulation Of Progesterone Secretion
  • Positive Regulation Of Smooth Muscle Cell Migration
  • Positive Regulation Of Smooth Muscle Cell Proliferation
  • Positive Regulation Of Synaptic Transmission
  • Response To Insulin
  • Response To Mechanical Stimulus
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 2535| adipocyte specific secreted hormone| adipose-specific cysteine-rich secreted protein A12-alpha| adipose tissue-specific secretory factor| ADSF| BcDNA:LD35748| c/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein| C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1| CG5403 gene product from transcript CG5403-RB| CG5403-PA| CG5403-PB| CG5403-PC| CG5403-PD| CG5403-PE| cysteine-rich secreted protein A12-alpha-like 2| cysteine-rich secreted protein FIZZ3| dead ringer| dead-ringer| Dead Ringer/Retain| Dmel_CG5403| dominant inhibitory adipocyte-specific secretory factor| dri| EHMT| EY2-10| FIZZ3| found in inflammatory zone 3| GW7_02488| H920_15616| PAL_GLEAN10002128| PANDA_010890| resistin delta2| retained| RETN1| retn/dri| retn-PA| retn-PB| retn-PC| retn-PD| retn-PE| Rstn| TREES_T100020101| UY3_19129| XCP1| Xcp4| Y1Q_003247| retn

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