Summary of RETN
The gene codes for a protein, resistin. The hormone is links obesity to type II diabetes [R].
The Function of RETN
Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.
Protein names
Recommended name:
ResistinShort name:
ADSFAlternative name(s):
Adipose tissue-specific secretory factorC/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein
Cysteine-rich secreted protein A12-alpha-like 2
Cysteine-rich secreted protein FIZZ3
- RS1423096 (RETN) ??
- RS1862513 (RETN) ??
- RS3219175 (RETN) ??
- RS3745367 (RETN) ??
- RS3745369 (RETN) ??
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Top Gene-Substance Interactions
RETN Interacts with These Diseases
| Disease | Score |
Substances That Increase RETN
| Substances | Interaction | Organism | Category |
Substances That Decrease RETN
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Diabetes mellitus type 2
From NCBI Gene: This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010] From UniProt: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed only in fatty tissues.
Molecular Function:
Biological Processes:
- Aging
- Fat Cell Differentiation
- Negative Regulation Of Feeding Behavior
- Positive Regulation Of Collagen Metabolic Process
- Positive Regulation Of Progesterone Secretion
- Positive Regulation Of Smooth Muscle Cell Migration
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Positive Regulation Of Synaptic Transmission
- Response To Insulin
- Response To Mechanical Stimulus