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  3. RERE

RERE (Arginine-glutamic acid dipeptide repeats)

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The Function of RERE

Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.

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Protein names

Recommended name:

Arginine-glutamic acid dipeptide repeats protein

Alternative name(s):

Atrophin-1-like protein
Atrophin-1-related protein

RERE SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12025126 (RERE) ??
  2. RS2120461 (RERE) ??
  3. RS2252865 (RERE) ??
  4. RS301797 (RERE) ??
  5. RS301799 (RERE) ??
  6. RS301801 (RERE) ??
  7. RS301806 (RERE) ??
  8. RS3753275 (RERE) ??
  9. RS4908760 (RERE) ??

Top Gene-Substance Interactions

Substances That Increase RERE

Substances Interaction Organism Category

Substances That Decrease RERE

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Neurodevelopmental disorder with or without anomalies of the brain, eye, or heartFrom UniProt: A chromosomal aberration involving RERE is found in the neuroblastoma cell line NGP. Translocation t(1;15)(p36.2;q24).

     From NCBI Gene: This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] From UniProt: Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • RORalpha2
  • HNF-1
  • C/EBPalpha
  • IRF-2
  • Cdc5
  • Bach1
  • MIF-1
  • p300

Tissue specificity:

Widely expressed. Expressed in tumor cell lines.

Molecular Function:

  • Chromatin Binding
  • Poly-Glutamine Tract Binding
  • Rna Polymerase Ii Transcription Coactivator Activity
  • Rna Polymerase Ii Transcription Corepressor Activity
  • Sequence-Specific Dna Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Zinc Ion Binding

Biological Processes:

  • Branching Morphogenesis Of A Nerve
  • Cerebellar Granule Cell Precursor Proliferation
  • Cerebellar Purkinje Cell Layer Maturation
  • Chromatin Remodeling
  • Dendrite Morphogenesis
  • Nls-Bearing Protein Import Into Nucleus
  • Radial Glia Guided Migration Of Purkinje Cell
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ARG| arginine-glutamic acid dipeptide (RE) repeats| arginine-glutamic acid dipeptide repeat-containing protein| Arginine-glutamic acid dipeptide repeat protein| Arginine-glutamic acid dipeptide repeats protein| arginine glutamic acid dipeptide (RE) repeats| Arp| ATN1L| Atr2| atrophin-1 like protein| atrophin-1 related protein| atrophin-1-related protein| atrophin 2| atrophin-2| CB1_001955004| DNB1| eye<m03Jus>| eyes3| I79_020165| M91_12820| MDA_GLEAN10024416| N303_05197| N305_00920| N306_10054| N308_08328| N321_12622| N324_12100| N328_00963| N330_04405| N331_07546| N333_08316| NEDBEH| PAL_GLEAN10013041| PANDA_007226| TREES_T100008894| UY3_17004| Y1Q_002789| Z169_06782| rere

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