The Function of RERE
Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.
Protein names
Recommended name:
Arginine-glutamic acid dipeptide repeats proteinAlternative name(s):
Atrophin-1-like proteinAtrophin-1-related protein
- RS12025126 (RERE) ??
- RS2120461 (RERE) ??
- RS2252865 (RERE) ??
- RS301797 (RERE) ??
- RS301799 (RERE) ??
- RS301801 (RERE) ??
- RS301806 (RERE) ??
- RS3753275 (RERE) ??
- RS4908760 (RERE) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
Substances That Increase RERE
| Substances | Interaction | Organism | Category |
Substances That Decrease RERE
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Neurodevelopmental disorder with or without anomalies of the brain, eye, or heartFrom UniProt: A chromosomal aberration involving RERE is found in the neuroblastoma cell line NGP. Translocation t(1;15)(p36.2;q24).
From NCBI Gene: This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] From UniProt: Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed. Expressed in tumor cell lines.
Molecular Function:
- Rna Polymerase Ii Transcription Coactivator Activity
- Rna Polymerase Ii Transcription Corepressor Activity
- Chromatin Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Poly-Glutamine Tract Binding
- Zinc Ion Binding
- Sequence-Specific Dna Binding
Biological Processes:
- Chromatin Remodeling
- Nls-Bearing Protein Import Into Nucleus
- Cerebellar Purkinje Cell Layer Maturation
- Cerebellar Granule Cell Precursor Proliferation
- Radial Glia Guided Migration Of Purkinje Cell
- Branching Morphogenesis Of A Nerve
- Dendrite Morphogenesis