Summary of RELA
RELA is part of the NF-kappa-B complex. Nf-kB is an inflammatory protein that is essential for cytokine gene expression in T-cells. Also known as nuclear factor NF-kappa-B p65 subunit. RELA has also been shown to modulate immune responses, and activation of RELA is positively associated with multiple types of cancer.
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Protein names
Recommended name:
Transcription factor p65Alternative name(s):
Nuclear factor NF-kappa-B p65 subunitNuclear factor of kappa light polypeptide gene enhancer in B-cells 3
- RS732072 (RELA) ??
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Top Gene-Substance Interactions
RELA Interacts with These Diseases
| Disease | Score |
Substances That Increase RELA
| Substances | Interaction | Organism | Category |
Substances That Decrease RELA
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
- Toll-like receptor signaling pathway
- Prostate cancer
- B cell receptor signaling pathway
- TRAF6 Mediated Induction of proinflammatory cytokines
- Apoptosis
- Epithelial cell signaling in Helicobacter pylori infection
- Cytosolic DNA-sensing pathway
- Innate Immune System
- Shigellosis
- T cell receptor signaling pathway
- Tuberculosis
- Leishmaniasis
- Adipocytokine signaling pathway
- Toxoplasmosis
- MAPK signaling pathway
- Cellular responses to stress
- Measles
- Immune System
- Acute myeloid leukemia
- Pancreatic cancer
- Small cell lung cancer
- Neurotrophin signaling pathway
- RIG-I-like receptor signaling pathway
- Chemokine signaling pathway
- NOD-like receptor signaling pathway
- Hepatitis C
- Osteoclast differentiation
- Chagas disease (American trypanosomiasis)
- Pathways in cancer
- Amoebiasis
- Chronic myeloid leukemia
- Signal Transduction
Molecular Function:
- Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Distal Enhancer Sequence-Specific Dna Binding
- Transcription Factor Activity, Rna Polymerase Ii Core Promoter Sequence-Specific
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Dna Binding
- Chromatin Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Transcription Factor Binding
- Protein Kinase Binding
- Chromatin Dna Binding
- Ubiquitin Protein Ligase Binding
- Activating Transcription Factor Binding
- Phosphate Ion Binding
- Identical Protein Binding
- Protein Homodimerization Activity
- Actinin Binding
- Histone Deacetylase Binding
- Transcription Regulatory Region Dna Binding
- Protein Heterodimerization Activity
- Protein N-Terminus Binding
- Nf-Kappab Binding
- Repressing Transcription Factor Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Liver Development
- Hair Follicle Development
- Stimulatory C-Type Lectin Receptor Signaling Pathway
- Acetaldehyde Metabolic Process
- Inflammatory Response
- Cellular Defense Response
- Aging
- Positive Regulation Of Cell Proliferation
- Animal Organ Morphogenesis
- Response To Organic Substance
- Response To Uv-B
- Positive Regulation Of Schwann Cell Differentiation
- Cytokine-Mediated Signaling Pathway
- Membrane Protein Intracellular Domain Proteolysis
- Positive Regulation Of Chondrocyte Differentiation
- Positive Regulation Of Type I Interferon Production
- Response To Muramyl Dipeptide
- Response To Progesterone
- Response To Insulin
- Response To Cobalamin
- Cellular Response To Hepatocyte Growth Factor Stimulus
- Response To Muscle Stretch
- Fc-Epsilon Receptor Signaling Pathway
- Negative Regulation Of Protein Catabolic Process
- Negative Regulation Of Apoptotic Process
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Response To Amino Acid
- Response To Morphine
- Positive Regulation Of Interleukin-12 Biosynthetic Process
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Insulin Receptor Signaling Pathway
- Regulation Of Inflammatory Response
- T Cell Receptor Signaling Pathway
- Positive Regulation Of Nf-Kappab Transcription Factor Activity
- Response To Camp
- Defense Response To Virus
- Cellular Response To Hydrogen Peroxide
- Nucleotide-Binding Oligomerization Domain Containing 2 Signaling Pathway
- Response To Interleukin-1
- Cellular Response To Lipopolysaccharide
- Cellular Response To Nicotine
- Cellular Response To Interleukin-1
- Cellular Response To Interleukin-6
- Cellular Response To Tumor Necrosis Factor
- Cellular Response To Peptide Hormone Stimulus
- Negative Regulation Of Nik/Nf-Kappab Signaling
- Positive Regulation Of Pri-Mirna Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Mirna Metabolic Process
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway