Summary of RELA
RELA is part of the NF-kappa-B complex. Nf-kB is an inflammatory protein that is essential for cytokine gene expression in T-cells. Also known as nuclear factor NF-kappa-B p65 subunit. RELA has also been shown to modulate immune responses, and activation of RELA is positively associated with multiple types of cancer.
It's better to have this gene decreased
most of the time.
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
Transcription factor p65Alternative name(s):
Nuclear factor NF-kappa-B p65 subunitNuclear factor of kappa light polypeptide gene enhancer in B-cells 3
- RS732072 (RELA) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
RELA Interacts with These Diseases
| Disease | Score |
Substances That Increase RELA
| Substances | Interaction | Organism | Category |
Substances That Decrease RELA
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
- Immune System
- Small cell lung cancer
- Chagas disease (American trypanosomiasis)
- Tuberculosis
- Toxoplasmosis
- Pathways in cancer
- Epithelial cell signaling in Helicobacter pylori infection
- Leishmaniasis
- Toll-like receptor signaling pathway
- T cell receptor signaling pathway
- Neurotrophin signaling pathway
- Chemokine signaling pathway
- TRAF6 Mediated Induction of proinflammatory cytokines
- Osteoclast differentiation
- Measles
- NOD-like receptor signaling pathway
- Apoptosis
- Cellular responses to stress
- Prostate cancer
- Amoebiasis
- Adipocytokine signaling pathway
- Shigellosis
- MAPK signaling pathway
- Signal Transduction
- Innate Immune System
- RIG-I-like receptor signaling pathway
- B cell receptor signaling pathway
- Acute myeloid leukemia
- Chronic myeloid leukemia
- Pancreatic cancer
- Hepatitis C
- Cytosolic DNA-sensing pathway
Molecular Function:
- Actinin Binding
- Activating Transcription Factor Binding
- Chromatin Binding
- Chromatin Dna Binding
- Dna Binding
- Histone Deacetylase Binding
- Identical Protein Binding
- Nf-Kappab Binding
- Phosphate Ion Binding
- Protein Heterodimerization Activity
- Protein Homodimerization Activity
- Protein Kinase Binding
- Protein N-Terminus Binding
- Repressing Transcription Factor Binding
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Distal Enhancer Sequence-Specific Dna Binding
- Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcription Factor Activity, Rna Polymerase Ii Core Promoter Sequence-Specific
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Binding
- Transcription Regulatory Region Dna Binding
- Ubiquitin Protein Ligase Binding
Biological Processes:
- Acetaldehyde Metabolic Process
- Aging
- Animal Organ Morphogenesis
- Cellular Defense Response
- Cellular Response To Hepatocyte Growth Factor Stimulus
- Cellular Response To Hydrogen Peroxide
- Cellular Response To Interleukin-1
- Cellular Response To Interleukin-6
- Cellular Response To Lipopolysaccharide
- Cellular Response To Nicotine
- Cellular Response To Peptide Hormone Stimulus
- Cellular Response To Tumor Necrosis Factor
- Cytokine-Mediated Signaling Pathway
- Defense Response To Virus
- Fc-Epsilon Receptor Signaling Pathway
- Hair Follicle Development
- Inflammatory Response
- Liver Development
- Membrane Protein Intracellular Domain Proteolysis
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
- Negative Regulation Of Insulin Receptor Signaling Pathway
- Negative Regulation Of Nik/Nf-Kappab Signaling
- Negative Regulation Of Protein Catabolic Process
- Negative Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Nucleotide-Binding Oligomerization Domain Containing 2 Signaling Pathway
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Chondrocyte Differentiation
- Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
- Positive Regulation Of Interleukin-12 Biosynthetic Process
- Positive Regulation Of Mirna Metabolic Process
- Positive Regulation Of Nf-Kappab Transcription Factor Activity
- Positive Regulation Of Pri-Mirna Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Schwann Cell Differentiation
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Type I Interferon Production
- Regulation Of Inflammatory Response
- Response To Amino Acid
- Response To Camp
- Response To Cobalamin
- Response To Insulin
- Response To Interleukin-1
- Response To Morphine
- Response To Muramyl Dipeptide
- Response To Muscle Stretch
- Response To Organic Substance
- Response To Progesterone
- Response To Uv-B
- Stimulatory C-Type Lectin Receptor Signaling Pathway
- T Cell Receptor Signaling Pathway