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  3. RECK

RECK (Reversion inducing cysteine rich protein with kazal motifs)

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The Function of RECK

Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.

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Protein names

Recommended name:

Reversion-inducing cysteine-rich protein with Kazal motifs

Alternative name(s):

hRECK
Suppressor of tumorigenicity 15 protein

RECK SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11788747 (RECK) ??
  2. RS4878639 (RECK) ??

Top Gene-Substance Interactions

RECK Interacts with These Diseases

Disease Score

Substances That Increase RECK

Substances Interaction Organism Category

Substances That Decrease RECK

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Sp1

Tissue specificity:

Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells.

Molecular Function:

  • Endopeptidase Inhibitor Activity
  • Metalloendopeptidase Inhibitor Activity
  • Serine-Type Endopeptidase Inhibitor Activity

Biological Processes:

  • Blood Vessel Maturation
  • Embryo Implantation
  • Embryonic Forelimb Morphogenesis
  • Extracellular Matrix Organization
  • Negative Regulation Of Cell Migration
  • Negative Regulation Of Metalloendopeptidase Activity
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_09483| Anapl_12797| AS27_06593| AS28_15024| CG5392 gene product from transcript CG5392-RB| CG5392-PA| CG5392-PB| D623_10017847| Dmel_CG5392| GB18088| H920_03260| I79_020843| M91_10874| M959_11346| MDA_GLEAN10021584| membrane-anchored glycoprotein (metastasis and invasion)| membrane-anchored glycoprotein RECK| mRECK| N300_15277| N301_11918| N302_03208| N303_06804| N305_01761| N306_13844| N307_02055| N308_10840| N309_13165| N310_08634| N311_07242| N312_02791| N320_07746| N321_04391| N322_06273| N324_09347| N325_12398| N326_03502| N327_02406| N329_11594| N330_09001| N331_05417| N332_14750| N333_05532| N334_10347| N335_08199| N336_05775| nft| no food for thought| PAL_GLEAN10008066| PANDA_007496| Reck-PA| Reck-PB| Reversion-inducing cysteine-rich protein| reversion-inducing-cysteine-rich protein with Kasal motifs| Reversion-inducing cysteine-rich protein with Kazal motif| reversion-inducing cysteine-rich protein with Kazal motifs| Reversion-inducing-cysteine-rich protein with kazal motifs| Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK)| sdp| St15| suppression of tumorigenicity 15| suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs)| suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs)| suppressor of tumorigenicity 15 protein| UY3_11267| Y956_11805| Z169_01916| zmp:0000000982| reck

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