The Function of RECK
Negatively regulates matrix metalloproteinase-9 (MMP-9) by suppressing MMP-9 secretion and by direct inhibition of its enzymatic activity. RECK down-regulation by oncogenic signals may facilitate tumor invasion and metastasis. Appears to also regulate MMP-2 and MT1-MMP, which are involved in cancer progression.
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Protein names
Recommended name:
Reversion-inducing cysteine-rich protein with Kazal motifsAlternative name(s):
hRECKSuppressor of tumorigenicity 15 protein
- RS11788747 (RECK) ??
- RS4878639 (RECK) ??
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Top Gene-Substance Interactions
RECK Interacts with These Diseases
| Disease | Score |
Substances That Increase RECK
| Substances | Interaction | Organism | Category |
Substances That Decrease RECK
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in various tissues and untransformed cells. It is undetectable in tumor-derived cell lines and oncogenically transformed cells.
Molecular Function:
- Endopeptidase Inhibitor Activity
- Metalloendopeptidase Inhibitor Activity
- Serine-Type Endopeptidase Inhibitor Activity
Biological Processes:
- Blood Vessel Maturation
- Embryo Implantation
- Embryonic Forelimb Morphogenesis
- Extracellular Matrix Organization
- Negative Regulation Of Cell Migration
- Negative Regulation Of Metalloendopeptidase Activity