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  3. RCAN1

RCAN1 (Regulator of calcineurin 1)

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The Function of RCAN1

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.

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Protein names

Recommended name:

Calcipressin-1

Short name:

MCIP1

Alternative name(s):

Adapt78
Down syndrome critical region protein 1
Myocyte-enriched calcineurin-interacting protein 1
Regulator of calcineurin 1

RCAN1 SNPs

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  1. RS9305556 (RCAN1) ??

Top Gene-Substance Interactions

RCAN1 Interacts with These Diseases

Disease Score

Substances That Increase RCAN1

Substances Interaction Organism Category

Substances That Decrease RCAN1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • Egr-1
  • NF-kappaB1
  • GATA-1
  • GATA-2
  • GATA-3

Tissue specificity:

Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.

Induction:

By calcium.

Molecular Function:

  • Calcium-Dependent Protein Serine/Threonine Phosphatase Regulator Activity
  • Dna Binding
  • Identical Protein Binding
  • Nucleotide Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding

Biological Processes:

  • Blood Circulation
  • Calcineurin-Nfat Signaling Cascade
  • Central Nervous System Development
  • Regulation Of Calcineurin-Nfat Signaling Cascade
  • Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| calcineurin inhibitor| DSC1| csp1| Adapt78| Anapl_04515| AS27_04852| AS28_02925| calcipressin 1| calcipressin-1| calcium and oxidant-inducible mRNA| CALP1L| CB1_000995023| Down syndrome candidate region 1| Down syndrome critical region gene 1| Down syndrome critical region homolog 1| down syndrome critical region protein 1| Down syndrome critical region protein 1 homolog| dscr1| DSCR1-like protein| EH28_01176| H920_18227| I79_012453| M959_05757| Mcip1| MDA_GLEAN10011976| modulatory calcineurin-interacting protein 1| myocyte-enriched calcineurin-interacting protein 1| N300_07285| N301_07309| N302_03354| N303_13703| N305_06965| N306_09257| N307_12698| N308_11299| N309_03092| N310_03072| N311_00434| N312_07431| N320_05884| N321_02388| N322_07782| N324_01726| N325_03195| N326_12993| N327_11563| N328_10152| N329_10413| N330_04675| N331_12087| N332_07282| N333_01546| N334_07020| N335_02128| N336_11338| N339_05605| N340_13779| N341_12204| near DSCR proline-rich protein| Oxidative-induced protein Adapt78| PAL_GLEAN10025764| RCN1| TREES_T100019490| Y1Q_007166| Y956_04400| rcan1

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