The Function of RCAN1
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development.
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Protein names
Recommended name:
Calcipressin-1Short name:
MCIP1Alternative name(s):
Adapt78Down syndrome critical region protein 1
Myocyte-enriched calcineurin-interacting protein 1
Regulator of calcineurin 1
- RS9305556 (RCAN1) ??
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Top Gene-Substance Interactions
RCAN1 Interacts with These Diseases
| Disease | Score |
Substances That Increase RCAN1
| Substances | Interaction | Organism | Category |
Substances That Decrease RCAN1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed heart, brain and skeletal muscle. Also expressed in all other tissues.
Induction:
By calcium.
Molecular Function:
- Nucleotide Binding
- Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Identical Protein Binding
- Calcium-Dependent Protein Serine/Threonine Phosphatase Regulator Activity
Biological Processes:
- Signal Transduction
- Central Nervous System Development
- Blood Circulation
- Calcineurin-Nfat Signaling Cascade
- Regulation Of Calcineurin-Nfat Signaling Cascade