The Function of RBPJ
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788).
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Protein names
Recommended name:
Recombining binding protein suppressor of hairlessShort name:
CBF-1Alternative name(s):
J kappa-recombination signal-binding proteinRBP-J kappa
RBP-J
RBP-JK
Renal carcinoma antigen NY-REN-30
Top Gene-Substance Interactions
Substances That Increase RBPJ
| Substances | Interaction | Organism | Category |
Substances That Decrease RBPJ
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Caution:
Despite some similarity with the "phage" integrase family, it has no recombinase activity.
Molecular Function:
- Chromatin Binding
- Dna Binding
- Recombinase Activity
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Core Promoter Sequence-Specific Dna Binding
- Rna Polymerase Ii Repressing Transcription Factor Binding
- Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Binding
Biological Processes:
- Angiogenesis
- Arterial Endothelial Cell Fate Commitment
- Atrioventricular Canal Development
- Auditory Receptor Cell Fate Commitment
- B Cell Differentiation
- Blood Vessel Endothelial Cell Fate Specification
- Blood Vessel Lumenization
- Blood Vessel Remodeling
- Cardiac Left Ventricle Morphogenesis
- Clara Cell Differentiation
- Defense Response To Bacterium
- Dna Recombination
- Dorsal Aorta Morphogenesis
- Endocardium Morphogenesis
- Epidermal Cell Fate Specification
- Epithelial To Mesenchymal Transition
- Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
- Hair Follicle Maturation
- Humoral Immune Response
- Inflammatory Response To Antigenic Stimulus
- Interleukin-4 Secretion
- Keratinocyte Differentiation
- Labyrinthine Layer Blood Vessel Development
- Myeloid Dendritic Cell Differentiation
- Negative Regulation Of Cell Differentiation
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Ossification
- Negative Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Notch Signaling Involved In Heart Development
- Notch Signaling Pathway
- Outflow Tract Morphogenesis
- Pituitary Gland Development
- Positive Regulation Of Bmp Signaling Pathway
- Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment
- Positive Regulation Of Cardiac Muscle Cell Proliferation
- Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
- Positive Regulation Of Ephrin Receptor Signaling Pathway
- Positive Regulation Of Erbb Signaling Pathway
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Hypoxia
- Positive Regulation Of Transcription Of Notch Receptor Target
- Regulation Of Timing Of Cell Differentiation
- Regulation Of Transcription From Rna Polymerase Ii Promoter Involved In Myocardial Precursor Cell Differentiation
- Sebaceous Gland Development
- Secondary Heart Field Specification
- Somatic Stem Cell Population Maintenance
- Somitogenesis
- Transcription Initiation From Rna Polymerase Ii Promoter
- Ventricular Trabecula Myocardium Morphogenesis