The Function of RBPJ
Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788).
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Protein names
Recommended name:
Recombining binding protein suppressor of hairlessShort name:
CBF-1Alternative name(s):
J kappa-recombination signal-binding proteinRBP-J kappa
RBP-J
RBP-JK
Renal carcinoma antigen NY-REN-30
Top Gene-Substance Interactions
Substances That Increase RBPJ
| Substances | Interaction | Organism | Category |
Substances That Decrease RBPJ
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Caution:
Despite some similarity with the "phage" integrase family, it has no recombinase activity.
Molecular Function:
- Recombinase Activity
- Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Dna Binding
- Rna Polymerase Ii Core Promoter Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Rna Polymerase Ii Repressing Transcription Factor Binding
- Dna Binding
- Chromatin Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Binding
- Sequence-Specific Dna Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Angiogenesis
- Somitogenesis
- Epithelial To Mesenchymal Transition
- Blood Vessel Remodeling
- Inflammatory Response To Antigenic Stimulus
- Secondary Heart Field Specification
- Outflow Tract Morphogenesis
- Endocardium Morphogenesis
- Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
- Cardiac Left Ventricle Morphogenesis
- Ventricular Trabecula Myocardium Morphogenesis
- Regulation Of Transcription From Rna Polymerase Ii Promoter Involved In Myocardial Precursor Cell Differentiation
- Dna Recombination
- Transcription Initiation From Rna Polymerase Ii Promoter
- Humoral Immune Response
- Notch Signaling Pathway
- Positive Regulation Of Transcription Of Notch Receptor Target
- Negative Regulation Of Cell Proliferation
- Auditory Receptor Cell Fate Commitment
- Epidermal Cell Fate Specification
- Pituitary Gland Development
- B Cell Differentiation
- Keratinocyte Differentiation
- Negative Regulation Of Ossification
- Positive Regulation Of Bmp Signaling Pathway
- Somatic Stem Cell Population Maintenance
- Dorsal Aorta Morphogenesis
- Atrioventricular Canal Development
- Defense Response To Bacterium
- Myeloid Dendritic Cell Differentiation
- Negative Regulation Of Cell Differentiation
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Timing Of Cell Differentiation
- Sebaceous Gland Development
- Hair Follicle Maturation
- Positive Regulation Of Cardiac Muscle Cell Proliferation
- Clara Cell Differentiation
- Labyrinthine Layer Blood Vessel Development
- Arterial Endothelial Cell Fate Commitment
- Notch Signaling Involved In Heart Development
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter In Response To Hypoxia
- Blood Vessel Lumenization
- Interleukin-4 Secretion
- Blood Vessel Endothelial Cell Fate Specification
- Positive Regulation Of Erbb Signaling Pathway
- Positive Regulation Of Ephrin Receptor Signaling Pathway
- Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment
- Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis