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  3. RASL11A

RASL11A (RAS like family 11 member A)

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The Function of RASL11A

Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription.

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Protein names

Recommended name:

Ras-like protein family member 11A

RASL11A SNPs

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  1. RS10507380 (RASL11A) ??
  2. RS9512637 (RASL11A) ??

Top Gene-Substance Interactions

Substances That Increase RASL11A

Substances Interaction Organism Category

Substances That Decrease RASL11A

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53
  • C/EBPalpha
  • MEF-2A
  • IRF-2
  • c-Rel
  • Lmo2
  • Msx-1

Tissue specificity:

Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder and aorta. Lowest levels observed in endothelial cells.

Induction:

Down-regulated by TGFB1.

Developmental stage:

Down-regulated during development of THP-1 monocytes into macrophages.

Caution:

Although highly related to the Ras family, lacks the conserved prenylation motif at the C-terminus, which serves to target Ras proteins to membrane compartments.

Molecular Function:

  • Gtp Binding

Biological Processes:

  • Positive Regulation Of Transcription From Rna Polymerase I Promoter
  • Small Gtpase Mediated Signal Transduction
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_03135| AS28_02402| D623_10001618| EGK_09191| GW7_12527| H920_05227| I79_002113| M91_00439| M959_06270| MDA_GLEAN10008288| N300_09448| N302_00909| N303_02103| N307_02338| N309_14746| N330_01022| N332_09057| N340_01195| PANDA_016984| RAS-like family 11 member A| RAS-like, family 11, member A| Ras-like family member 11A| ras-like protein family member 11A| ras-like protein family member 11A-like| ras-like protein family member 11A-like protein| RSLBL| TREES_T100009458| UY3_05218| Y1Q_004046| rasl11a

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