The Function of RASL11A
Regulator of rDNA transcription. Acts in cooperation UBF/UBTF and positively regulates RNA polymerase I transcription.
Protein names
Recommended name:
Ras-like protein family member 11A- RS10507380 (RASL11A) ??
- RS9512637 (RASL11A) ??
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Top Gene-Substance Interactions
Substances That Increase RASL11A
| Substances | Interaction | Organism | Category |
Substances That Decrease RASL11A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed. Down-regulated in prostate tumors compared to normal prostate tissue. High levels found in colon tumor and normal colon tissue followed by small intestine, liver, jejunum, ileum, bladder and aorta. Lowest levels observed in endothelial cells.
Induction:
Down-regulated by TGFB1.
Developmental stage:
Down-regulated during development of THP-1 monocytes into macrophages.
Caution:
Although highly related to the Ras family, lacks the conserved prenylation motif at the C-terminus, which serves to target Ras proteins to membrane compartments.
Molecular Function:
Biological Processes:
- Transcription, Dna-Templated
- Small Gtpase Mediated Signal Transduction
- Positive Regulation Of Transcription From Rna Polymerase I Promoter