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  3. RAPGEF1

RAPGEF1 (Rap guanine nucleotide exchange factor 1)

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The Function of RAPGEF1

Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.

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Protein names

Recommended name:

Rap guanine nucleotide exchange factor 1

Alternative name(s):

CRK SH3-binding GNRP
Guanine nucleotide-releasing factor 2
Protein C3G

RAPGEF1 SNPs

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  1. RS11243437 (RAPGEF1) ??

Top Gene-Substance Interactions

Substances That Increase RAPGEF1

Substances Interaction Organism Category

Substances That Decrease RAPGEF1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • NF-kappaB1

Tissue specificity:

Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver.

Molecular Function:

  • Rap Guanyl-Nucleotide Exchange Factor Activity

Biological Processes:

  • Activation Of Mapkk Activity
  • Blood Vessel Development
  • Cellular Response To Camp
  • Cellular Response To Nerve Growth Factor Stimulus
  • Establishment Of Endothelial Barrier
  • Negative Regulation Of Canonical Wnt Signaling Pathway
  • Negative Regulation Of Erk1 And Erk2 Cascade
  • Negative Regulation Of Neural Precursor Cell Proliferation
  • Negative Regulation Of Protein Kinase B Signaling
  • Negative Regulation Of Ras Protein Signal Transduction
  • Nerve Growth Factor Signaling Pathway
  • Platelet-Derived Growth Factor Receptor Signaling Pathway
  • Positive Regulation Of Gtpase Activity
  • Positive Regulation Of Neuron Projection Development
  • Rap Protein Signal Transduction
  • Regulation Of Cell Junction Assembly
  • Signal Transduction
  • Single Organismal Cell-Cell Adhesion
  • Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS27_01619| AS28_01142| C3g| C3G-1| C3G-2| CB1_000576090| CRK SH3-binding GNRP| D623_10010151| GRF2| guanine nucleotide releasing factor 2| guanine nucleotide-releasing factor 2| guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene)| H920_06693| I79_022484| M91_15839| M959_09394| MDA_GLEAN10011202| N300_09382| N301_12420| N302_13119| N303_06145| N305_08959| N306_14759| N307_02491| N308_09265| N309_07154| N310_08061| N311_12862| N312_07751| N320_10843| N321_03736| N324_02890| N325_11975| N326_08416| N327_04773| N328_03902| N329_05657| N330_05411| N331_06167| N332_14239| N333_00810| N335_09454| N336_09919| N339_01244| N340_07754| PAL_GLEAN10012567| rap guanine nucleotide exchange factor 1-like protein| Rap guanine nucleotide exchange factor (GEF) 1| TREES_T100016430| UY3_08240| Y1Q_020297| Y956_02083| Z169_11696| rapgef1

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