The Function of RAPGEF1
Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.
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Protein names
Recommended name:
Rap guanine nucleotide exchange factor 1Alternative name(s):
CRK SH3-binding GNRPGuanine nucleotide-releasing factor 2
Protein C3G
- RS11243437 (RAPGEF1) ??
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Top Gene-Substance Interactions
Substances That Increase RAPGEF1
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Substances That Decrease RAPGEF1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver.
Molecular Function:
Biological Processes:
- Activation Of Mapkk Activity
- Blood Vessel Development
- Signal Transduction
- Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
- Positive Regulation Of Neuron Projection Development
- Single Organismal Cell-Cell Adhesion
- Rap Protein Signal Transduction
- Nerve Growth Factor Signaling Pathway
- Positive Regulation Of Gtpase Activity
- Negative Regulation Of Ras Protein Signal Transduction
- Platelet-Derived Growth Factor Receptor Signaling Pathway
- Negative Regulation Of Protein Kinase B Signaling
- Establishment Of Endothelial Barrier
- Negative Regulation Of Erk1 And Erk2 Cascade
- Cellular Response To Camp
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Regulation Of Cell Junction Assembly
- Cellular Response To Nerve Growth Factor Stimulus
- Negative Regulation Of Neural Precursor Cell Proliferation