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  3. RAP2A

RAP2A (RAP2A, member of RAS oncogene family)

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The Function of RAP2A

Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.

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RAP2A SNPs

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  1. RS4771996 (RAP2A) ??

Top Gene-Substance Interactions

RAP2A Interacts with These Diseases

Disease Score

Substances That Increase RAP2A

Substances Interaction Organism Category

Substances That Decrease RAP2A

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • FOXO1a
  • FOXO1

Enzyme Regulation:

Activated by the guanine nucleotide-exchange factors RAPGEF3 and RAPGEF4 in a cAMP-dependent manner. Nucleotide exchange is also specifically stimulated by RAPGEF5, RASGEF1A and RASGEF1B.

Molecular Function:

  • Gtp Binding
  • Gtpase Activity

Biological Processes:

  • Actin Cytoskeleton Reorganization
  • Cellular Protein Localization
  • Establishment Of Protein Localization
  • Microvillus Assembly
  • Negative Regulation Of Cell Migration
  • Positive Regulation Of Protein Autophosphorylation
  • Positive Regulation Of Protein Phosphorylation
  • Protein Localization To Plasma Membrane
  • Rap Protein Signal Transduction
  • Regulation Of Dendrite Morphogenesis
  • Regulation Of Jnk Cascade
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| K-REV| A306_03446| Anapl_15510| CB1_060782103| GW7_19066| H920_00786| krev| MDA_GLEAN10014497| N303_02876| N307_10549| PANDA_002847| rap2| Rap2A GTPase| rap2A-like protein| RAP2, member of RAS oncogene family (K-rev)| RAS related protein 2a| RAS related protein 2a inverted question mark| ras-related protein Rap-2a| ras-related protein Rap-2c| rbbp-30| TREES_T100006210| UY3_13114| Y1Q_000059| rap2a

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