The Function of RAP2A
Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it is part of several signaling cascades and may regulate cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading.
- RS4771996 (RAP2A) ??
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Top Gene-Substance Interactions
RAP2A Interacts with These Diseases
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Substances That Increase RAP2A
| Substances | Interaction | Organism | Category |
Substances That Decrease RAP2A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Enzyme Regulation:
Activated by the guanine nucleotide-exchange factors RAPGEF3 and RAPGEF4 in a cAMP-dependent manner. Nucleotide exchange is also specifically stimulated by RAPGEF5, RASGEF1A and RASGEF1B.
Molecular Function:
Biological Processes:
- Actin Cytoskeleton Reorganization
- Cellular Protein Localization
- Establishment Of Protein Localization
- Microvillus Assembly
- Negative Regulation Of Cell Migration
- Positive Regulation Of Protein Autophosphorylation
- Positive Regulation Of Protein Phosphorylation
- Protein Localization To Plasma Membrane
- Rap Protein Signal Transduction
- Regulation Of Dendrite Morphogenesis
- Regulation Of Jnk Cascade