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  3. RAP1GAP

RAP1GAP (RAP1 GTPase activating protein)

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Summary of RAP1GAP

The gene codes for a protein, RAP1 GTPase activating protein. The protein acts in cell proliferation, adhesion, differentiation, and embryogenesis  [R].

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The Function of RAP1GAP

GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.

Protein names

Recommended name:

Rap1 GTPase-activating protein 1

Alternative name(s):

Rap1GAP
Rap1GAP1

RAP1GAP SNPs

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  1. RS829417 (RAP1GAP) ??

Top Gene-Substance Interactions

RAP1GAP Interacts with These Diseases

Disease Score

Substances That Increase RAP1GAP

Substances Interaction Organism Category

Substances That Decrease RAP1GAP

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun
  • c-Fos

Tissue specificity:

Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues.

Gene Pathways:

  • Immune System

Induction:

By 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells.

Molecular Function:

  • Gtpase Activator Activity
  • Gtpase Activity
  • Protein Homodimerization Activity
  • Ras Gtpase Binding

Biological Processes:

  • Cellular Response To Glial Cell Derived Neurotrophic Factor
  • Negative Regulation Of Gtp Binding
  • Negative Regulation Of Microvillus Assembly
  • Negative Regulation Of Neuron Differentiation
  • Negative Regulation Of Thyroid Gland Epithelial Cell Proliferation
  • Positive Regulation Of Gtpase Activity
  • Regulation Of Gtpase Activity
  • Regulation Of Small Gtpase Mediated Signal Transduction
  • Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ARPP-90| AS27_05514| AS28_01381| D623_10012703| Gap| I79_010490| M91_17449| M959_04160| N301_07453| N302_04344| N306_14146| N307_10701| N309_05376| N310_13477| N312_06603| N320_03093| N321_12841| N322_05945| N324_03919| N326_03694| N327_12954| N328_10139| N329_10983| N330_03947| N331_01791| N332_08124| N333_13012| N334_07565| N335_00873| N336_08015| N340_02144| N341_08321| PAL_GLEAN10015192| PANDA_008206| rap1ga1| Rap1GAP1| RAP1GAPII| Rap1 GTPase-activating protein| Rap1 GTPase-activating protein 1| rap1 GTPase-activating protein 1-like| rapgap| UY3_18087| Y1Q_025683| Y956_07977| rap1gap

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