Summary of RAP1GAP
The gene codes for a protein, RAP1 GTPase activating protein. The protein acts in cell proliferation, adhesion, differentiation, and embryogenesis [R].
0 users want this gene increased,
0 users want it decreased
The Function of RAP1GAP
GTPase activator for the nuclear Ras-related regulatory protein RAP-1A (KREV-1), converting it to the putatively inactive GDP-bound state.
Protein names
Recommended name:
Rap1 GTPase-activating protein 1Alternative name(s):
Rap1GAPRap1GAP1
- RS829417 (RAP1GAP) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
RAP1GAP Interacts with These Diseases
| Disease | Score |
Substances That Increase RAP1GAP
| Substances | Interaction | Organism | Category |
Substances That Decrease RAP1GAP
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Significant expression seen in the brain, kidney and pancreas. Abundant in the cerebral cortex and expressed at much lower levels in the spinal cord. Not detected in the lymphoid tissues.
Gene Pathways:
Induction:
By 12-O-tetradecanoylphorbol-13-acetate (TPA) in promyelocytic HL-60 cells.
Molecular Function:
Biological Processes:
- Cellular Response To Glial Cell Derived Neurotrophic Factor
- Negative Regulation Of Gtp Binding
- Negative Regulation Of Microvillus Assembly
- Negative Regulation Of Neuron Differentiation
- Negative Regulation Of Thyroid Gland Epithelial Cell Proliferation
- Positive Regulation Of Gtpase Activity
- Regulation Of Gtpase Activity
- Regulation Of Small Gtpase Mediated Signal Transduction
- Signal Transduction