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RAC2 (Ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2))

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Summary of RAC2

The gene codes for a protein, ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2). Mutations are linked to neutrophil immunodeficiency syndrome. A pseudogene is on chromosome 6 [R].

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The Function of RAC2

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.

Protein names

Recommended name:

Ras-related C3 botulinum toxin substrate 2

Short name:

GX

Alternative name(s):

Small G protein
p21-Rac2

RAC2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS13058338 (RAC2) ??
  2. RS2239774 (RAC2) ??

Top Gene-Substance Interactions

RAC2 Interacts with These Diseases

Disease Score

Substances That Increase RAC2

Substances Interaction Organism Category

Substances That Decrease RAC2

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Neutrophil immunodeficiency syndromeFrom UniProt: Neutrophil immunodeficiency syndrome (NEUID): An immunodeficiency syndrome due to defective neutrophils. Affected individuals present with leukocytosis, neutrophilia, severe recurrent bacterial infections and poor wound healing. [MIM:608203]

     From NCBI Gene: This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013] From UniProt: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase .

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun
  • STAT3

Tissue specificity:

Hematopoietic specific.

Gene Pathways:

  • MAPK signaling pathway
  • Pathways in cancer
  • Regulation of actin cytoskeleton
  • Signal Transduction
  • Wnt signaling pathway
  • Hemostasis
  • Natural killer cell mediated cytotoxicity
  • Adherens junction
  • Colorectal cancer
  • Leukocyte transendothelial migration
  • Axon guidance
  • Chemokine signaling pathway
  • B cell receptor signaling pathway
  • Pancreatic cancer
  • Phagosome
  • VEGF signaling pathway
  • Fc epsilon RI signaling pathway
  • Viral myocarditis

Enzyme Regulation:

Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.

Molecular Function:

  • Gtpase Activity
  • Gtp Binding
  • Protein Kinase Regulator Activity

Biological Processes:

  • Actin Filament Organization
  • Bone Resorption
  • Cell Projection Assembly
  • Chemotaxis
  • G-Protein Coupled Receptor Signaling Pathway
  • Lymphocyte Aggregation
  • Platelet Activation
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Lamellipodium Assembly
  • Positive Regulation Of Neutrophil Chemotaxis
  • Positive Regulation Of Protein Targeting To Mitochondrion
  • Regulation Of Cell-Substrate Adhesion
  • Regulation Of Hydrogen Peroxide Metabolic Process
  • Regulation Of Mast Cell Chemotaxis
  • Regulation Of Mast Cell Degranulation
  • Regulation Of Neutrophil Migration
  • Regulation Of Respiratory Burst
  • Regulation Of Small Gtpase Mediated Signal Transduction
  • Regulation Of T Cell Proliferation
  • Signal Transduction
  • Small Gtpase Mediated Signal Transduction

Drug Bank:

  • Dextromethorphan
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_16079| AS27_07840| AS28_09522| CB1_000175036| CDC42| CG8556 gene product from transcript CG8556-RB| CG8556-PA| CG8556-PB| Dmel_CG8556| DmRAC2| Drac1b| Drac2| D-Rac2| D-Rac 2| DRacB| EGK_03011| EN-7| EN-7 protein| GW7_03672| Gx| H920_01934| HSPC022| I79_022271| M959_13984| MDA_GLEAN10009813| N300_11515| N301_10203| N302_12683| N303_09879| N305_14051| N306_00905| N307_05139| N308_09955| N309_04772| N310_07302| N311_11057| N312_02542| N320_02246| N321_09009| N322_12972| N324_05982| N326_07346| N329_12119| N330_04402| N331_05432| N332_05109| N333_04835| N336_03778| N339_04965| p21-Rac2| P48554| PAL_GLEAN10002087| PANDA_002485| protein EN-7| Rac| Rac1| Rac1b| Rac-2| Rac2-PA| Rac2-PB| Rac2 protein| RacB| Rac GTPase| Rac protein| RAS-related C3 botulinum substrate 2| ras-related C3 botulinum toxin substrate 2| ras-related C3 botulinum toxin substrate 2 (rho family, small GT| Ras-related C3 botulinum toxin substrate 3 (rho family, small GTP-binding protein Rac2)| ras-related protein| small G protein| TREES_T100008203| UY3_09697| Y1Q_025093| Y956_01184| Z169_12009| rac2

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