The Function of RAB8B
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells.
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Protein names
Recommended name:
Ras-related protein Rab-8B- RS1986112 (RAB8B) ??
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Top Gene-Substance Interactions
Substances That Increase RAB8B
| Substances | Interaction | Organism | Category |
Substances That Decrease RAB8B
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
Biological Processes:
- Vesicle Docking Involved In Exocytosis
- Small Gtpase Mediated Signal Transduction
- Protein Secretion
- Antigen Processing And Presentation
- Positive Regulation Of Cell Projection Organization
- Adherens Junction Organization
- Protein Import Into Peroxisome Membrane
- Positive Regulation Of Corticotropin Secretion