The Function of RAB32
Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes.
Protein names
Recommended name:
Ras-related protein Rab-32- RS13220141 (RAB32) ??
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Top Gene-Substance Interactions
RAB32 Interacts with These Diseases
| Disease | Score |
Substances That Increase RAB32
| Substances | Interaction | Organism | Category |
Substances That Decrease RAB32
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung.
Enzyme Regulation:
Regulated by a guanine nucleotide-exchange factor (GEF) and a GTPase-activating protein (GAP) and alternates between an inactive GDP-bound and an active GTP-bound form. The BLOC-3 complex composed of HPS1 and HPS4 acts as its GEF, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (By similarity). SGSM2 acts as its GAP and inactivates it by stimulating its GTPase activity (PubMed:21269460).
Molecular Function:
- Ap-1 Adaptor Complex Binding
- Ap-3 Adaptor Complex Binding
- Bloc-2 Complex Binding
- Gtpase Activity
- Gtp Binding
- Gtp-Dependent Protein Binding
Biological Processes:
- Antigen Processing And Presentation
- Endosome To Melanosome Transport
- Melanosome Assembly
- Mitochondrion Organization
- Phagosome Maturation
- Protein Localization To Membrane
- Small Gtpase Mediated Signal Transduction