The Function of RAB31
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
Protein names
Recommended name:
Ras-related protein Rab-31Alternative name(s):
Ras-related protein Rab-22B- RS7233332 (RAB31) ??
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Top Gene-Substance Interactions
Substances That Increase RAB31
| Substances | Interaction | Organism | Category |
Substances That Decrease RAB31
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highest expression in placenta and brain with lower levels in heart and lung. Not detected in liver, skeletal muscle, kidney or pancreas.
Molecular Function:
Biological Processes:
- Small Gtpase Mediated Signal Transduction
- Receptor Internalization
- Cellular Response To Insulin Stimulus
- Golgi To Plasma Membrane Protein Transport
- Regulated Exocytosis
- Golgi Vesicle Transport
- Phagosome Maturation