The Function of RAB1B
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum.
Protein names
Recommended name:
Ras-related protein Rab-1BTop Gene-Substance Interactions
Substances That Increase RAB1B
| Substances | Interaction | Organism | Category |
Substances That Decrease RAB1B
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Enzyme Regulation:
Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP).
Molecular Function:
Biological Processes:
- Er To Golgi Vesicle-Mediated Transport
- Retrograde Vesicle-Mediated Transport, Golgi To Er
- Autophagy
- Small Gtpase Mediated Signal Transduction
- Protein Transport
- Virion Assembly
- Copii Vesicle Coating
- Positive Regulation Of Glycoprotein Metabolic Process
- Regulation Of Autophagosome Assembly