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  3. RAB1B

RAB1B (RAB1B, member RAS oncogene family)

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The Function of RAB1B

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum.

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Protein names

Recommended name:

Ras-related protein Rab-1B

Top Gene-Substance Interactions

Substances That Increase RAB1B

Substances Interaction Organism Category

Substances That Decrease RAB1B

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • PPAR-gamma1
  • PPAR-gamma2
  • c-Jun
  • PPAR-alpha
  • YY1
  • Pax-5

Enzyme Regulation:

Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP).

Molecular Function:

  • Gtp Binding

Biological Processes:

  • Autophagy
  • Copii Vesicle Coating
  • Er To Golgi Vesicle-Mediated Transport
  • Positive Regulation Of Glycoprotein Metabolic Process
  • Protein Transport
  • Regulation Of Autophagosome Assembly
  • Retrograde Vesicle-Mediated Transport, Golgi To Er
  • Small Gtpase Mediated Signal Transduction
  • Virion Assembly
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| GW7_07189| MDA_GLEAN10017872| PANDA_004764| Rab1bl| RAB1B-like, member RAS oncogene family| Ras-related protein Rab-1B| ras-related protein Rab-1B pseudogene| small GTP-binding protein| rab1b

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