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  3. RAB12

RAB12 (RAB12, member RAS oncogene family)

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The Function of RAB12

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy.

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Protein names

Recommended name:

Ras-related protein Rab-12

RAB12 SNPs

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  1. RS12185468 (RAB12) ??
  2. RS12458130 (RAB12) ??
  3. RS9961574 (RAB12) ??

Top Gene-Substance Interactions

RAB12 Interacts with These Diseases

Disease Score

Substances That Increase RAB12

Substances Interaction Organism Category

Substances That Decrease RAB12

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • STAT3

Enzyme Regulation:

Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (By similarity). That Rab is activated by DENND3, a guanine exchange factor.

Molecular Function:

  • Gdp Binding
  • Gtp Binding

Biological Processes:

  • Autophagy
  • Cellular Protein Catabolic Process
  • Endosome To Lysosome Transport
  • Positive Regulation Of Macroautophagy
  • Protein Transport
  • Small Gtpase Mediated Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_07293| Anapl_06617| AS27_05805| AS28_10352| C77700| CB1_000932032| D623_10029811| EH28_01856| H920_11474| I79_010577| M91_16977| M959_00995| MDA_GLEAN10019451| N300_05316| N301_04861| N302_08972| N303_01594| N305_03488| N306_04864| N307_14902| N308_00766| N309_07221| N310_08243| N311_03757| N312_04907| N320_04561| N321_01129| N322_08828| N324_12862| N325_05579| N326_01586| N327_11052| N328_10539| N329_05674| N330_04275| N331_07454| N332_12041| N333_00880| N334_01322| N336_02345| N339_01929| N340_11807| N341_12074| PAL_GLEAN10023217| PANDA_005963| putative Ras-related protein Rab-12| rab-13| ras-related protein Rab-12| ras-related protein Rab-12-like| UY3_09402| Y1Q_019972| Y956_15429| Z169_02874| rab12

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