The Function of RAB12
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy.
Protein names
Recommended name:
Ras-related protein Rab-12- RS12185468 (RAB12) ??
- RS12458130 (RAB12) ??
- RS9961574 (RAB12) ??
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Top Gene-Substance Interactions
RAB12 Interacts with These Diseases
| Disease | Score |
Substances That Increase RAB12
| Substances | Interaction | Organism | Category |
Substances That Decrease RAB12
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Enzyme Regulation:
Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (By similarity). That Rab is activated by DENND3, a guanine exchange factor.
Molecular Function:
Biological Processes:
- Autophagy
- Cellular Protein Catabolic Process
- Endosome To Lysosome Transport
- Positive Regulation Of Macroautophagy
- Protein Transport
- Small Gtpase Mediated Signal Transduction