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  3. PYGB

PYGB (Glycogen phosphorylase B)

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The Function of PYGB

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

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Protein names

Recommended name:

Glycogen phosphorylase, brain form

PYGB SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS139672965 (PYGB) ??
  2. RS2281558 (PYGB) ??

Top Gene-Substance Interactions

Substances That Increase PYGB

Substances Interaction Organism Category

Substances That Decrease PYGB

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • HSF2

Gene Pathways:

  • Metabolism
  • Disease
  • Insulin signaling pathway
  • Starch and sucrose metabolism

Enzyme Regulation:

Activity of phosphorylase is controlled both by allosteric means (through the non-covalent binding of metabolites) and by covalent modification. Thus AMP allosterically activates, whereas ATP, ADP, and glucose-6-phosphate allosterically inhibit, phosphorylase B.

Molecular Function:

  • Glycogen Phosphorylase Activity
  • Pyridoxal Phosphate Binding

Biological Processes:

  • Glycogen Catabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_11973| AS27_06129| AS28_06157| brain glycogen phosphorylase| D623_10026401| glycogen phosphorylase B| glycogen phosphorylase, brain form| GLYPHOA| GPBB| GP BB| H920_05935| I79_006118| M91_20803| M959_11209| MDA_GLEAN10004502| N300_05396| N301_10140| N302_15188| N305_02540| N306_12864| N307_10449| N308_05823| N309_13989| N310_07728| N311_04764| N320_11256| N322_05221| N324_04428| N330_04131| N331_03755| N333_10806| N334_03563| N335_13746| N339_02737| PAL_GLEAN10002747| PANDA_020753| TREES_T100008144| Y1Q_029693| Y956_12661| Z169_03193| pygb

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