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  3. PXR

PXR (Mannosidase alpha class 2A member 1)

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Summary of PXR

PXR increases CYP3A4, which is needed to metabolize a bunch of drugs and toxins. CYP3A4 is important in phase I detox.  In addition, PXR increases phase II enzymes such as glutathione S-transferase and phase III detox proteins such as OATP2 and MDR1 (Ref) Bottom line:  PXR is needed to detox drugs and is also important in decreasing inflammation.

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Protein names

Recommended name:

Nuclear receptor subfamily 1 group I member 2

Short name:

SXR

Alternative name(s):

Orphan nuclear receptor PAR1
Orphan nuclear receptor PXR
Pregnane X receptor
Steroid and xenobiotic receptor

PXR SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1523127 (PXR) ??
  2. RS2472682 (PXR) ??
  3. RS6785049 (PXR) ??

Fixes

FIX:  PPARa(R) , PGC-1a (R), Progesterones (R), Pregnenolones (R), Corticosterones (R), Testosterone (R), DHEA , Estradiol (R), 5-²-pregnene-3,20-dione (R), Lithocholic acid (R), St Johns Wort /Hyperforin (strong) (R), K2 (weak) (R), Bile acids/ Bile Acid Conjugates/TUDCA (R), Curcumin (R), Resveratrol (R)

Advanced Summary

PXR increases CYP3A4, which is needed to metabolize a bunch of drugs and toxins. CYP3A4 is important in phase I detox.  In addition, PXR increases phase II enzymes such as glutathione S-transferase and phase III detox proteins such as OATP2 and MDR1 (Ref) Bottom line:  PXR is needed to detox drugs and is also important in decreasing inflammation.

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