Summary of PXR
PXR increases CYP3A4, which is needed to metabolize a bunch of drugs and toxins. CYP3A4 is important in phase I detox. In addition, PXR increases phase II enzymes such as glutathione S-transferase and phase III detox proteins such as OATP2 and MDR1 (Ref) Bottom line: PXR is needed to detox drugs and is also important in decreasing inflammation.
Protein names
Recommended name:
Nuclear receptor subfamily 1 group I member 2Short name:
SXRAlternative name(s):
Orphan nuclear receptor PAR1Orphan nuclear receptor PXR
Pregnane X receptor
Steroid and xenobiotic receptor
- RS1523127 (PXR) ??
- RS2472682 (PXR) ??
- RS6785049 (PXR) ??
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Fixes
FIX: PPARa(R) , PGC-1a (R), Progesterones (R), Pregnenolones (R), Corticosterones (R), Testosterone (R), DHEA , Estradiol (R), 5-²-pregnene-3,20-dione (R), Lithocholic acid (R), St Johns Wort /Hyperforin (strong) (R), K2 (weak) (R), Bile acids/ Bile Acid Conjugates/TUDCA (R), Curcumin (R), Resveratrol (R)
Advanced Summary
PXR increases CYP3A4, which is needed to metabolize a bunch of drugs and toxins. CYP3A4 is important in phase I detox. In addition, PXR increases phase II enzymes such as glutathione S-transferase and phase III detox proteins such as OATP2 and MDR1 (Ref) Bottom line: PXR is needed to detox drugs and is also important in decreasing inflammation.