The Function of PXK
Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.
Protein names
Recommended name:
PX domain-containing protein kinase-like proteinAlternative name(s):
Modulator of Na,K-ATPaseMONaKA
- RS11714574 (PXK) ??
- RS13315871 (PXK) ??
- RS2176082 (PXK) ??
- RS6445975 (PXK) ??
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Top Gene-Substance Interactions
PXK Interacts with These Diseases
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Substances That Increase PXK
| Substances | Interaction | Organism | Category |
Substances That Decrease PXK
| Substances | Interaction | Organism | Category |
Advanced Summary
Covered on Genetics Home Reference: rheumatoid arthritis
From NCBI Gene: This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] From UniProt: Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high levels in the brain, skeletal muscle, spleen and testis. Isoform 7 expression has yet to be demonstrated.
Molecular Function:
Biological Processes:
- Inflammatory Response
- Negative Regulation Of Atpase Activity
- Regulation Of Membrane Potential
- Negative Regulation Of Ion Transport
- Modulation Of Synaptic Transmission