• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. PXK

PXK (PX domain containing serine/threonine kinase like)

Loading...

The Function of PXK

Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

PX domain-containing protein kinase-like protein

Alternative name(s):

Modulator of Na,K-ATPase
MONaKA

PXK SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11714574 (PXK) ??
  2. RS13315871 (PXK) ??
  3. RS2176082 (PXK) ??
  4. RS6445975 (PXK) ??

Top Gene-Substance Interactions

PXK Interacts with These Diseases

Disease Score

Substances That Increase PXK

Substances Interaction Organism Category

Substances That Decrease PXK

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: rheumatoid arthritis

     From NCBI Gene: This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] From UniProt: Binds to and modulates brain Na,K-ATPase subunits ATP1B1 and ATP1B3 and may thereby participate in the regulation of electrical excitability and synaptic transmission. May not display kinase activity.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • IRF-1
  • TBP
  • IRF-2
  • Cdc5
  • TFIID

Tissue specificity:

Widely expressed in all tissues examined except in heart. Isoform 1 is expressed in high levels in the brain, skeletal muscle, spleen and testis. Isoform 7 expression has yet to be demonstrated.

Molecular Function:

  • Phosphatidylinositol Binding
  • Protein C-Terminus Binding

Biological Processes:

  • Inflammatory Response
  • Modulation Of Synaptic Transmission
  • Negative Regulation Of Atpase Activity
  • Negative Regulation Of Ion Transport
  • Regulation Of Membrane Potential
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_06525| AS27_11648| AS28_12603| D14Ertd813e| D623_10027640| H920_13417| M959_08630| modulator of Na,K-ATPase| modulator of Na,K-ATPase long form| MONaKA| N300_04475| N301_01324| N302_10249| N303_14501| N305_00255| N307_09967| N308_05151| N309_04909| N312_10138| N320_08895| N321_13667| N322_04500| N328_00944| N329_10182| N330_04767| N331_06685| N332_03550| N333_07595| N335_09235| N336_03604| N341_10766| PANDA_001391| PX domain-containing protein kinase-like| PX domain-containing protein kinase-like protein| PX domain containing serine/threonine kinase| PX domain-containing serine/threonine kinase| Pxk_0| PX serine/threonine kinase| PX ser/thr kinase v2| TREES_T100010261| Y1Q_014687| Y956_14377| pxk

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved