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  3. PTPRO

PTPRO (Protein tyrosine phosphatase, receptor type O)

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The Function of PTPRO

Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function.

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Protein names

Recommended name:

Receptor-type tyrosine-protein phosphatase O

Short name:

PTP-U2

Alternative name(s):

R-PTP-O
Glomerular epithelial protein 1
Protein tyrosine phosphatase U2
PTPase U2

PTPRO SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2300290 (PTPRO) ??

Top Gene-Substance Interactions

PTPRO Interacts with These Diseases

Disease Score

Substances That Increase PTPRO

Substances Interaction Organism Category

Substances That Decrease PTPRO

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • RORalpha1
  • FAC1
  • Cdc5

Tissue specificity:

Glomerulus of kidney. Also detected in brain, lung and placenta.

Induction:

By various differentiation-inducing agents.

Molecular Function:

  • Phosphatase Activity
  • Protein Homodimerization Activity
  • Protein Tyrosine Phosphatase Activity
  • Transmembrane Receptor Protein Tyrosine Phosphatase Activity
  • Wnt-Protein Binding

Biological Processes:

  • Axon Guidance
  • Cell Morphogenesis
  • Glomerular Visceral Epithelial Cell Differentiation
  • Glomerulus Development
  • Lamellipodium Assembly
  • Monocyte Chemotaxis
  • Negative Regulation Of Canonical Wnt Signaling Pathway
  • Negative Regulation Of Cell-Substrate Adhesion
  • Negative Regulation Of Glomerular Filtration
  • Negative Regulation Of Neuron Projection Development
  • Negative Regulation Of Retinal Ganglion Cell Axon Guidance
  • Peptidyl-Tyrosine Dephosphorylation
  • Protein Dephosphorylation
  • Regulation Of Glomerular Filtration
  • Slit Diaphragm Assembly
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| PTP| A306_10382| Anapl_05587| AS27_06212| AS28_09058| D28| D623_10031441| extracellular protein tyrosine phosphatase CRYP-2| GLEPP1| glomerular epithelial protein 1| H920_11394| I79_007229| M91_21459| M959_01503| N300_06644| N301_16189| N302_04713| N303_11585| N305_11980| N306_14664| N307_01856| N309_10484| N310_13674| N312_03189| N321_02880| N324_04400| N325_12773| N326_09309| N327_06978| N332_04141| N333_11876| N334_07315| N335_01675| N336_02255| NPHS6| osteoclastic phosphotyrosyl phosphatase| osteoclastic transmembrane protein-tyrosine phosphatase| PAL_GLEAN10015647| phosphotyrosine phosphatase U2| protein tyrosine phosphatase, non-receptor type 15| protein tyrosine phosphatase PTP-U2| protein tyrosine phosphatase, receptor type, O| protein tyrosine phosphatase U2| PTPase U2| PTPBK| Ptpn15| PTPoc| PTP-OC| PTPphi| PTP phi| PTPROT| PTPU2| PTP-U2| receptor protein tyrosine phosphatase RO| receptor-type protein tyrosine phosphatase D30| receptor-type tyrosine-protein phosphatase-like| Receptor-type tyrosine-protein phosphatase O| RPTP-BK| R-PTP-O| TREES_T100003658| UY3_07781| Y1Q_006650| Y956_08051| Z169_15533| ptpro

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