The Function of PTPRO
Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function.
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Protein names
Recommended name:
Receptor-type tyrosine-protein phosphatase OShort name:
PTP-U2Alternative name(s):
R-PTP-OGlomerular epithelial protein 1
Protein tyrosine phosphatase U2
PTPase U2
- RS2300290 (PTPRO) ??
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Top Gene-Substance Interactions
PTPRO Interacts with These Diseases
| Disease | Score |
Substances That Increase PTPRO
| Substances | Interaction | Organism | Category |
Substances That Decrease PTPRO
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Glomerulus of kidney. Also detected in brain, lung and placenta.
Induction:
By various differentiation-inducing agents.
Molecular Function:
- Phosphatase Activity
- Protein Homodimerization Activity
- Protein Tyrosine Phosphatase Activity
- Transmembrane Receptor Protein Tyrosine Phosphatase Activity
- Wnt-Protein Binding
Biological Processes:
- Axon Guidance
- Cell Morphogenesis
- Glomerular Visceral Epithelial Cell Differentiation
- Glomerulus Development
- Lamellipodium Assembly
- Monocyte Chemotaxis
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Negative Regulation Of Cell-Substrate Adhesion
- Negative Regulation Of Glomerular Filtration
- Negative Regulation Of Neuron Projection Development
- Negative Regulation Of Retinal Ganglion Cell Axon Guidance
- Peptidyl-Tyrosine Dephosphorylation
- Protein Dephosphorylation
- Regulation Of Glomerular Filtration
- Slit Diaphragm Assembly