The Function of PTPRJ
Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.
Protein names
Recommended name:
Receptor-type tyrosine-protein phosphatase etaShort name:
DEP-1Alternative name(s):
Protein-tyrosine phosphatase etaR-PTP-eta
Density-enhanced phosphatase 1
HPTP eta
Protein-tyrosine phosphatase receptor type J
R-PTP-J
CD antigen CD148
- RS10838798 (PTPRJ) ??
- RS10838801 (PTPRJ) ??
- RS10838809 (PTPRJ) ??
- RS11039571 (PTPRJ) ??
- RS138315285 (PTPRJ) ??
- RS1503185 (PTPRJ) ??
- RS1566734 (PTPRJ) ??
- RS1681630 (PTPRJ) ??
- RS3942852 (PTPRJ) ??
- RS747782 (PTPRJ) ??
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Top Gene-Substance Interactions
Substances That Increase PTPRJ
| Substances | Interaction | Organism | Category |
Substances That Decrease PTPRJ
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in the promyelocytic cell line HL-60, the granulocyte-macrophage colony-stimulating factor-dependent leukemic cell line F-36P, and the IL3 and erythropoietin-dependent leukemic cell line F-36E. Expressed predominantly in epithelial cells and lymphocytes. Enhanced expression at high cell density.
Gene Pathways:
Molecular Function:
- Protein Tyrosine Phosphatase Activity
- Platelet-Derived Growth Factor Receptor Binding
- Beta-Catenin Binding
- Phosphatase Activity
- Protein Kinase Binding
- Gamma-Catenin Binding
- Mitogen-Activated Protein Kinase Binding
- Delta-Catenin Binding
Biological Processes:
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Platelet-Derived Growth Factor Receptor Signaling Pathway
- Regulation Of Cell Adhesion
- Negative Regulation Of Cell Growth
- Negative Regulation Of Cell Migration
- Peptidyl-Tyrosine Dephosphorylation
- Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
- Negative Regulation Of Vascular Permeability
- Negative Regulation Of Map Kinase Activity
- Positive Regulation Of Cell Adhesion
- Platelet-Derived Growth Factor Receptor Signaling Pathway
- T Cell Receptor Signaling Pathway
- Negative Regulation Of T Cell Receptor Signaling Pathway
- Positive Chemotaxis
- Positive Regulation Of Focal Adhesion Assembly
- Positive Regulation Of Protein Kinase B Signaling
- Negative Regulation Of Protein Kinase B Signaling
- Contact Inhibition