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PTPN22 (Protein tyrosine phosphatase, non-receptor type 22)

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Summary of PTPN22

The PTPN22 gene encodes a protein that belongs to the PTP (protein tyrosine phosphatases) family. They regulate signal transduction; the signals instruct the cell to grow and divide or to mature and take on specialized functions (R).

The PTPN22 protein is involved in the signaling of T cells; T cells identify foreign substances and defend the body against infection. Mutations of this gene can cause many different autoimmune disorders, including: Graves disease, rheumatoid arthritis, lupus, Addison disease, etc (R).

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The Function of PTPN22

Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106).

Protein names

Recommended name:

Tyrosine-protein phosphatase non-receptor type 22

Alternative name(s):

Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
Lymphoid phosphatase
LyP
PEST-domain phosphatase
PEP

PTPN22 SNPs

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  1. RS1217407 (PTPN22) ??
  2. RS1217413 (PTPN22) ??
  3. RS12730735 (PTPN22) ??
  4. RS1310182 (PTPN22) ??
  5. RS1599971 (PTPN22) ??
  6. RS2476599 (PTPN22) ??
  7. RS2476601 (PTPN22) ??
  8. RS2488457 (PTPN22) ??
  9. RS33996649 (PTPN22) ??
  10. RS3765598 (PTPN22) ??
  11. RS3811021 (PTPN22) ??
  12. RS6679677 (PTPN22) ??

Top Gene-Substance Interactions

PTPN22 Interacts with These Diseases

Disease Score

Substances That Increase PTPN22

Substances Interaction Organism Category

Substances That Decrease PTPN22

Substances Interaction Organism Category

Advanced Summary

The PTPN22 gene encodes a protein that belongs to the PTP (protein tyrosine phosphatases) family. They regulate signal transduction; the signals instruct the cell to grow and divide or to mature and take on specialized functions (R).

The PTPN22 protein is involved in the signaling of T cells; T cells identify foreign substances and defend the body against infection. Mutations of this gene can cause many different autoimmune disorders, including: Graves disease, rheumatoid arthritis, lupus, Addison disease, etc (R).

     autoimmune Addison disease Genetics Home Reference provides information about autoimmune Addison disease. Graves disease Genetics Home Reference provides information about Graves disease. idiopathic inflammatory myopathy Genetics Home Reference provides information about idiopathic inflammatory myopathy. juvenile idiopathic arthritis Genetics Home Reference provides information about juvenile idiopathic arthritis. rheumatoid arthritis Genetics Home Reference provides information about rheumatoid arthritis. systemic lupus erythematosus Genetics Home Reference provides information about systemic lupus erythematosus. systemic scleroderma Genetics Home Reference provides information about systemic scleroderma. type 1 diabetes Genetics Home Reference provides information about type 1 diabetes. vitiligo Studies have associated the R620W variation in the PTPN22 gene with an increased risk of vitiligo, an autoimmune condition that results in patchy changes in skin coloring (pigmentation). As with other autoimmune disorders, this variation likely affects the activity of the PTPN22 protein, making it more difficult for the body to control the immune system and prevent it from attacking its own tissues. While the pigment loss associated with vitiligo results from the immune system attacking pigment-producing cells (melanocytes) in the skin, it is unclear what specific circumstances trigger the immune system to do so. The condition probably results from a combination of genetic and environmental factors, most of which have not been identified. autoimmune disorders Studies have associated a variation in the PTPN22 gene with an increased risk of several autoimmune disorders. Autoimmune disorders occur when the immune system malfunctions and attacks the body's tissues and organs. These disorders include type 1 diabetes, rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. The PTPN22 gene variation associated with autoimmune disorders changes the protein building block (amino acid) arginine to the amino acid tryptophan at position 620 in the PTPN22 protein sequence, written as Arg620Trp or R620W. This variation likely affects the activity of the PTPN22 protein, making it more difficult for the body to control inflammation and prevent the immune system from attacking its own tissues.

     The PTPN22 gene provides instructions for making a protein that belongs to the PTP (protein tyrosine phosphatases) family. PTP proteins play a role in regulating a process called signal transduction. In signal transduction, the protein relays signals from outside the cell to the cell nucleus. These signals instruct the cell to grow and divide or to mature and take on specialized functions. The PTPN22 protein is involved in signaling that helps control the activity of immune system cells called T cells. T cells identify foreign substances and defend the body against infection.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • NF-kappaB1

Tissue specificity:

Expressed in bone marrow, B and T-cells, PBMCs, natural killer cells, monocytes, dendritic cells and neutrophils (PubMed:15208781). Both isoform 1 and 4 are predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells.

Induction:

By muramyl-dipeptide and lipopolysaccharide.

Enzyme Regulation:

Down-regulated by phosphorylation.

Molecular Function:

  • Kinase Binding
  • Phosphatase Activity
  • Protein Tyrosine Phosphatase Activity
  • Sh3 Domain Binding
  • Ubiquitin Protein Ligase Binding

Biological Processes:

  • Autophagy
  • Cellular Response To Muramyl Dipeptide
  • Lipopolysaccharide-Mediated Signaling Pathway
  • Negative Regulation Of Autophagy
  • Negative Regulation Of Gene Expression
  • Negative Regulation Of Interleukin-6 Secretion
  • Negative Regulation Of Interleukin-8 Secretion
  • Negative Regulation Of Jun Kinase Activity
  • Negative Regulation Of Nucleotide-Binding Oligomerization Domain Containing 2 Signaling Pathway
  • Negative Regulation Of P38mapk Cascade
  • Negative Regulation Of T Cell Activation
  • Negative Regulation Of T Cell Receptor Signaling Pathway
  • Negative Regulation Of Tumor Necrosis Factor Production
  • Phosphoanandamide Dephosphorylation
  • Positive Regulation Of Erk1 And Erk2 Cascade
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Interferon-Gamma Secretion
  • Positive Regulation Of Protein K63-Linked Ubiquitination
  • Positive Regulation Of Toll-Like Receptor 3 Signaling Pathway
  • Positive Regulation Of Toll-Like Receptor 4 Signaling Pathway
  • Positive Regulation Of Type I Interferon Production
  • Protein Dephosphorylation
  • Regulation Of B Cell Receptor Signaling Pathway
  • Regulation Of Innate Immune Response
  • Regulation Of Natural Killer Cell Proliferation
  • Regulation Of Nik/Nf-Kappab Signaling
  • Response To Lipopolysaccharide
  • T Cell Differentiation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ptpn12| 70zpep| A306_10186| AS27_01930| AS28_04379| GW7_01191| hematopoietic cell protein-tyrosine phosphatase 70Z-PEP| lymphoid-specific protein tyrosine phosphatase| LYP| LYP1| LYP2| MDA_GLEAN10024796| N301_00789| N302_14705| N303_11078| N307_02108| N308_09300| N309_01818| N310_01058| N312_01143| N320_06726| N321_06973| N327_13018| N331_09992| N332_07227| N333_02650| N335_11566| N340_09078| PANDA_006718| PEP| PEST domain-enriched tyrosine phosphatase| PEST-domain phosphatase| protein-tyrosine phosphatase LyPTP| protein tyrosine phosphatase, non-receptor type 22 (lymphoid)| protein tyrosine phosphatase, non-receptor type 8| protein-tyrosine phosphatase PEST| Ptpn8| TREES_T100005371| tyrosine-protein phosphatase non-receptor type 22| tyrosine-protein phosphatase non-receptor type 22-like protein| Y956_09027| ptpn22

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