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  3. PTN

PTN (Pleiotrophin)

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The Function of PTN

Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777).

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Protein names

Recommended name:

Pleiotrophin

Short name:

PTN

Alternative name(s):

Heparin-binding brain mitogen
HBBM
Heparin-binding growth factor 8
HBGF-8
Heparin-binding growth-associated molecule
HB-GAM
Heparin-binding neurite outgrowth-promoting factor 1
HBNF-1
Osteoblast-specific factor 1
OSF-1

Top Gene-Substance Interactions

PTN Interacts with These Diseases

Disease Score

Substances That Increase PTN

Substances Interaction Organism Category

Substances That Decrease PTN

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1
  • c-Fos
  • IRF-1
  • GATA-2
  • GATA-3

Tissue specificity:

Osteoblast and brain.

Induction:

By heparin and retinoic acid.

Molecular Function:

  • Chondroitin Sulfate Binding
  • Chondroitin Sulfate Proteoglycan Binding
  • Growth Factor Activity
  • Heparan Sulfate Binding
  • Heparin Binding
  • Protein Phosphatase Inhibitor Activity

Biological Processes:

  • Bone Mineralization
  • Cellular Response To Hypoxia
  • Cellular Response To Platelet-Derived Growth Factor Stimulus
  • Cellular Response To Uv
  • Cellular Response To Vitamin D
  • Cerebellum Development
  • Endothelial Cell Differentiation
  • Estrous Cycle
  • Heart Development
  • Learning
  • Liver Development
  • Long-Term Synaptic Potentiation
  • Lung Development
  • Negative Regulation Of Angiogenesis
  • Negative Regulation Of Cell Migration
  • Negative Regulation Of Epithelial Cell Proliferation
  • Negative Regulation Of Glial Cell Proliferation
  • Negative Regulation Of Membrane Potential
  • Negative Regulation Of Mesenchymal Cell Proliferation
  • Negative Regulation Of Neuromuscular Junction Development
  • Nervous System Development
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Cell Division
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Cell-Substrate Adhesion
  • Positive Regulation Of Hepatocyte Proliferation
  • Positive Regulation Of Neuron Projection Development
  • Positive Regulation Of Skeletal Muscle Acetylcholine-Gated Channel Clustering
  • Regulation Of Cell Shape
  • Response To Ciliary Neurotrophic Factor
  • Response To Estradiol
  • Response To Kainic Acid
  • Response To Nerve Growth Factor
  • Response To Progesterone
  • Retinal Rod Cell Differentiation
  • Rod Bipolar Cell Differentiation
  • Spinal Cord Development
  • Thalamus Development
  • Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| p18| A306_07760| AS27_12464| AS28_09125| CB1_000082002| D623_10008646| EGK_14173| GW7_21662| H920_08493| harp| HBBM| HBBN| HB-GAM| hbgf8| HBGF-8| hbnf| HBNF-1| heparin affine regulatory peptide| heparin affin regulatory peptide| heparin affin regulatory protein| heparin-binding brain mitogen| heparin binding factor| heparin-binding growth-associated molecule| heparin binding growth factor 8| heparin-binding growth factor 8| heparin-binding neurite outgrowth promoting factor| heparin-binding neurite outgrowth-promoting factor 1| heparin-binding neurite promoting factor| heparin-binding neurite-promoting factor| heparin-binding neurotorphic factor| heparin-binding neurotrophic factor| heparin-binding neutrophic factor| I79_007305| M959_14934| MDA_GLEAN10007727| N300_04846| N301_15032| N302_07270| N303_05584| N305_07876| N306_01222| N307_12198| N308_00416| N309_04834| N310_01171| N311_12927| N312_13099| N321_05349| N322_12018| N324_10549| N325_05405| N326_11577| N327_13251| N328_03673| N329_10808| N330_01106| N331_00395| N332_06740| N333_13106| N334_02699| N335_02565| N336_05330| N339_03887| N340_12409| N341_05672| negf1| neurite growth-promoting factor 1| OSF| Osf1| OSF-1| osteoblastic cell factor| osteoblast-specific factor 1| PAL_GLEAN10019096| PANDA_002130| pleiotrophic factor beta| pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)| Pleiotrophin (Heparine binding factor, Hbnf, in the mouse)| PTF-BETA| TREES_T100005118| UY3_18963| X-PTF| Y1Q_011252| Y956_13804| Z169_03582| zHBNF| ptn

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