The Function of PTH
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
Protein names
Recommended name:
Parathyroid hormoneShort name:
PTHAlternative name(s):
ParathormoneParathyrin
- RS6254 (PTH) ??
- RS6256 (PTH) ??
- RS7927727 (PTH) ??
- RS9630182 (PTH) ??
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Top Gene-Substance Interactions
PTH Interacts with These Diseases
| Disease | Score |
Substances That Increase PTH
| Substances | Interaction | Organism | Category |
Substances That Decrease PTH
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Hypoparathyroidism familial isolatedFrom UniProt: Hypoparathyroidism, familial isolated (FIH): A disorder characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone . Clinical features include seizures, tetany and cramps. [MIM:146200]
From NCBI Gene: This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] From UniProt: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Hormone Activity
- Parathyroid Hormone Receptor Binding
- Peptide Hormone Receptor Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Skeletal System Development
- Cellular Calcium Ion Homeostasis
- G-Protein Coupled Receptor Signaling Pathway
- Adenylate Cyclase-Activating G-Protein Coupled Receptor Signaling Pathway
- Rho Protein Signal Transduction
- Cell-Cell Signaling
- Hormone-Mediated Apoptotic Signaling Pathway
- Positive Regulation Of Signal Transduction
- Response To Lead Ion
- Regulation Of Gene Expression
- Positive Regulation Of Bone Mineralization
- Positive Regulation Of Camp Biosynthetic Process
- Response To Vitamin D
- Cellular Macromolecule Biosynthetic Process
- Bone Resorption
- Response To Ethanol
- Positive Regulation Of Glycogen Biosynthetic Process
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Camp Metabolic Process
- Positive Regulation Of Glucose Import
- Response To Cadmium Ion
- Homeostasis Of Number Of Cells Within A Tissue
- Response To Parathyroid Hormone
- Response To Fibroblast Growth Factor
- Positive Regulation Of Cell Proliferation In Bone Marrow
- Negative Regulation Of Apoptotic Process In Bone Marrow
- Positive Regulation Of Osteoclast Proliferation