The Function of PTH
PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
Protein names
Recommended name:
Parathyroid hormoneShort name:
PTHAlternative name(s):
ParathormoneParathyrin
- RS6254 (PTH) ??
- RS6256 (PTH) ??
- RS7927727 (PTH) ??
- RS9630182 (PTH) ??
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Top Gene-Substance Interactions
PTH Interacts with These Diseases
| Disease | Score |
Substances That Increase PTH
| Substances | Interaction | Organism | Category |
Substances That Decrease PTH
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Hypoparathyroidism familial isolatedFrom UniProt: Hypoparathyroidism, familial isolated (FIH): A disorder characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone . Clinical features include seizures, tetany and cramps. [MIM:146200]
From NCBI Gene: This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can result in hypocalcemia and numbness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015] From UniProt: PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Hormone Activity
- Parathyroid Hormone Receptor Binding
- Peptide Hormone Receptor Binding
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
Biological Processes:
- Adenylate Cyclase-Activating G-Protein Coupled Receptor Signaling Pathway
- Bone Resorption
- Camp Metabolic Process
- Cell-Cell Signaling
- Cellular Calcium Ion Homeostasis
- Cellular Macromolecule Biosynthetic Process
- G-Protein Coupled Receptor Signaling Pathway
- Homeostasis Of Number Of Cells Within A Tissue
- Hormone-Mediated Apoptotic Signaling Pathway
- Negative Regulation Of Apoptotic Process In Bone Marrow
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Bone Mineralization
- Positive Regulation Of Camp Biosynthetic Process
- Positive Regulation Of Cell Proliferation In Bone Marrow
- Positive Regulation Of Glucose Import
- Positive Regulation Of Glycogen Biosynthetic Process
- Positive Regulation Of Osteoclast Proliferation
- Positive Regulation Of Signal Transduction
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Gene Expression
- Response To Cadmium Ion
- Response To Ethanol
- Response To Fibroblast Growth Factor
- Response To Lead Ion
- Response To Parathyroid Hormone
- Response To Vitamin D
- Rho Protein Signal Transduction
- Skeletal System Development