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  3. PTGS2

PTGS2 (Prostaglandin-endoperoxide synthase 2)

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Summary of PTGS2

This gene encodes a key enzyme in prostaglandin biosynthesis. It is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis (R). 

It's better to have this gene decreased most of the time.
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The Function of PTGS2

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.

Protein names

Recommended name:

Prostaglandin G/H synthase 2

Short name:

COX-2

Alternative name(s):

Cyclooxygenase-2
PHS II
Prostaglandin H2 synthase 2
PGH synthase 2
PGHS-2
Prostaglandin-endoperoxide synthase 2

PTGS2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10911902 (PTGS2) ??
  2. RS2066826 (PTGS2) ??
  3. RS2206593 (PTGS2) ??
  4. RS2745557 (PTGS2) ??
  5. RS4648261 (PTGS2) ??
  6. RS4648276 (PTGS2) ??
  7. RS4648298 (PTGS2) ??
  8. RS4648310 (PTGS2) ??
  9. RS5277 (PTGS2) ??
  10. RS689465 (PTGS2) ??
  11. RS689469 (PTGS2) ??
  12. RS689470 (PTGS2) ??

Top Gene-Substance Interactions

PTGS2 Interacts with These Diseases

Disease Score

Substances That Increase PTGS2

Substances Interaction Organism Category

Substances That Decrease PTGS2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • PPAR-gamma1
  • PPAR-gamma2
  • p53
  • CREB
  • AP-1
  • c-Jun
  • deltaCREB
  • NF-kappaB1
  • C/EBPbeta

Gene Pathways:

  • Metabolic pathways
  • Small cell lung cancer
  • Pathways in cancer
  • Leishmaniasis
  • Disease
  • Arachidonic acid metabolism
  • VEGF signaling pathway
  • Metabolism

Induction:

By cytokines and mitogens.

Cofactor:

Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.

Molecular Function:

  • Arachidonate 15-Lipoxygenase Activity
  • Enzyme Binding
  • Heme Binding
  • Lipid Binding
  • Metal Ion Binding
  • Peroxidase Activity
  • Prostaglandin-Endoperoxide Synthase Activity

Biological Processes:

  • Angiogenesis
  • Bone Mineralization
  • Brown Fat Cell Differentiation
  • Cellular Response To Atp
  • Cellular Response To Fluid Shear Stress
  • Cellular Response To Hypoxia
  • Cellular Response To Mechanical Stimulus
  • Cellular Response To Uv
  • Cyclooxygenase Pathway
  • Decidualization
  • Embryo Implantation
  • Hair Cycle
  • Inflammatory Response
  • Learning
  • Lipoxygenase Pathway
  • Maintenance Of Permeability Of Blood-Brain Barrier
  • Memory
  • Movement Of Cell Or Subcellular Component
  • Negative Regulation Of Calcium Ion Transport
  • Negative Regulation Of Cell Cycle
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Smooth Muscle Contraction
  • Negative Regulation Of Synaptic Transmission, Dopaminergic
  • Nicotinamide Metabolic Process
  • Ovulation
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Brown Fat Cell Differentiation
  • Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
  • Positive Regulation Of Fever Generation
  • Positive Regulation Of Fibroblast Growth Factor Production
  • Positive Regulation Of Nf-Kappab Import Into Nucleus
  • Positive Regulation Of Nitric Oxide Biosynthetic Process
  • Positive Regulation Of Platelet-Derived Growth Factor Production
  • Positive Regulation Of Prostaglandin Biosynthetic Process
  • Positive Regulation Of Smooth Muscle Cell Proliferation
  • Positive Regulation Of Smooth Muscle Contraction
  • Positive Regulation Of Synaptic Plasticity
  • Positive Regulation Of Synaptic Transmission, Glutamatergic
  • Positive Regulation Of Transforming Growth Factor Beta Production
  • Positive Regulation Of Vascular Endothelial Growth Factor Production
  • Positive Regulation Of Vasoconstriction
  • Prostaglandin Biosynthetic Process
  • Prostaglandin Metabolic Process
  • Regulation Of Blood Pressure
  • Regulation Of Inflammatory Response
  • Response To Estradiol
  • Response To Fatty Acid
  • Response To Fructose
  • Response To Glucocorticoid
  • Response To Lipopolysaccharide
  • Response To Lithium Ion
  • Response To Manganese Ion
  • Response To Oxidative Stress
  • Response To Tumor Necrosis Factor
  • Response To Vitamin D
  • Sensory Perception Of Pain

Drug Bank:

  • Acetylsalicylic Acid
  • Clodronate
  • Desmopressin
  • Dihomo-Gamma-Linolenic Acid
  • Etanercept
  • Icosapent
  • Aldesleukin
  • Aminosalicylic Acid
  • Antipyrine
  • Antrafenine
  • Bromfenac
  • Bumetanide
  • Capsaicin
  • Carprofen
  • Chlorphenesin
  • Cisplatin
  • Dapsone
  • Diclofenac
  • Diflunisal
  • Drospirenone
  • Etoposide
  • Etoricoxib
  • Fenoprofen
  • Flurbiprofen
  • Ginseng
  • Ibuprofen
  • Ketoprofen
  • Mesalazine
  • Nonoxynol-9
  • Risedronate
  • Salsalate
  • Trisalicylate-Choline
  • Lenalidomide
  • Lornoxicam
  • Lumiracoxib
  • Meclofenamic Acid
  • Mefenamic Acid
  • Meloxicam
  • Nabumetone
  • Naproxen
  • Nepafenac
  • Nimesulide
  • Oxaprozin
  • Parecoxib
  • Phenylbutazone
  • Piroxicam
  • Pomalidomide
  • Sulfasalazine
  • Sulindac
  • Suprofen
  • Tafluprost
  • Tenoxicam
  • Thalidomide
  • Tiaprofenic Acid
  • Tolmetin
  • Triamcinolone
  • Acetaminophen
  • Balsalazide
  • Celecoxib
  • Etodolac
  • Indomethacin
  • Ketorolac
  • Magnesium Salicylate
  • Niflumic Acid
  • Salicylic Acid
  • Tetrahydrobiopterin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| cox2| PGG/HS| prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)| prostaglandin G/H synthase and cyclooxygenase| A306_11740| Anapl_16693| AS27_12714| AS28_06004| CB1_000818013| CEF147| cox-2| cyclooxygenase 2| cyclooxygenase-2| cyclooxygenase 2b| cyclooxygenase, prostaglandin endoperoxide H synthase-2| cyclooxygenase type 2| cylooxygenase-2| EGK_01845| glucocorticoid-regulated inflammatory cyclooxygenase| gripghs| GW7_07100| hcox-2| M959_12540| macrophage activation-associated marker protein P71/73| MDA_GLEAN10017472| mitogen-inducible PGHS| N300_14684| N301_05346| N302_03591| N303_02407| N305_10959| N306_00799| N307_07900| N308_02142| N309_03148| N310_06708| N311_13120| N312_02444| N320_13302| N321_14280| N322_00380| N324_01715| N325_01031| N326_05650| N327_12240| N329_07171| N330_09212| N331_12363| N332_13193| N333_02724| N334_02610| N336_12631| N339_02331| N340_12168| N341_09593| PAL_GLEAN10017647| PANDA_014299| PES-2| PGH2S| pghs-2| Pghs2| PGH synthase 2| phs-2| PHSII| PHS II| prostaglandin endoperoxidase synthase 2| prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthas| prostaglandin G/H synthase-2| Prostaglandin G/H synthase 2| prostaglandin G/H synthase 2-like protein| prostaglandin H2 synthase 2| prostaglandin H synthase-2| TIS10| TREES_T100016374| UY3_04102| Y1Q_024578| Y956_06386| Z169_07310| ptgs2

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