The Function of PTGS1
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
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Protein names
Recommended name:
Prostaglandin G/H synthase 1Short name:
COX-1Alternative name(s):
Cyclooxygenase-1Prostaglandin H2 synthase 1
PGH synthase 1
PGHS-1
PHS 1
Prostaglandin-endoperoxide synthase 1
- RS10306114 (PTGS1) ??
- RS3842788 (PTGS1) ??
- RS5789 (PTGS1) ??
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Top Gene-Substance Interactions
PTGS1 Interacts with These Diseases
| Disease | Score |
Substances That Increase PTGS1
| Substances | Interaction | Organism | Category |
Substances That Decrease PTGS1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Cofactor:
Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
Molecular Function:
- Dioxygenase Activity
- Heme Binding
- Metal Ion Binding
- Peroxidase Activity
- Prostaglandin-Endoperoxide Synthase Activity
- Lipid Binding
Biological Processes:
- Cyclooxygenase Pathway
- Inflammatory Response
- Lipid Metabolic Process
- Prostaglandin Biosynthetic Process
- Regulation Of Blood Pressure
- Regulation Of Cell Proliferation
- Response To Oxidative Stress
- Xenobiotic Metabolic Process
- Aging
- Learning
- Memory
- Negative Regulation Of Epinephrine Secretion
- Negative Regulation Of Norepinephrine Secretion
- Positive Regulation Of Smooth Muscle Contraction
- Positive Regulation Of Vasoconstriction
- Response To Corticosterone
- Response To Fatty Acid
- Response To Organonitrogen Compound
- Sensory Perception Of Pain
Drug Bank:
- Acetylsalicylic Acid
- Desmopressin
- Dihomo-Gamma-Linolenic Acid
- Dronabinol
- Icosapent
- Imatinib
- Mesalazine
- Salsalate
- Antipyrine
- Antrafenine
- Bortezomib
- Bromfenac
- Candesartan
- Carprofen
- Chlorpropamide
- Dapsone
- Diazepam
- Diclofenac
- Diethylcarbamazine
- Diflunisal
- Eletriptan
- Eszopiclone
- Etodolac
- Etoposide
- Flurbiprofen
- Hexobarbital
- Hydromorphone
- Ibuprofen
- Ifosfamide
- Indomethacin
- Irbesartan
- Ketobemidone
- Ketoprofen
- Ketorolac
- Lornoxicam
- Lumiracoxib
- Meclofenamic Acid
- Mefenamic Acid
- Meloxicam
- Minoxidil
- Montelukast
- Nabumetone
- Nateglinide
- Nepafenac
- Niflumic Acid
- Nortriptyline
- Oxaprozin
- Pioglitazone
- Piroxicam
- Rosiglitazone
- Salicylic Acid
- Sulfamethoxazole
- Torasemide
- Trisalicylate-Choline
- Sulindac
- Suprofen
- Tenoxicam
- Thalidomide
- Tiaprofenic Acid
- Tolmetin
- Trabectedin
- Valproic Acid
- Voriconazole
- Zafirlukast
- Zileuton
- Zolpidem
- Acetaminophen
- Balsalazide
- Carvedilol
- Diphenhydramine
- Fenoprofen
- Ketamine
- Magnesium Salicylate
- Naproxen
- Phenylbutazone
- Sulfasalazine
- Terbinafine
- Triflusal
- Zopiclone