The Function of PTGS1
Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.
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Protein names
Recommended name:
Prostaglandin G/H synthase 1Short name:
COX-1Alternative name(s):
Cyclooxygenase-1Prostaglandin H2 synthase 1
PGH synthase 1
PGHS-1
PHS 1
Prostaglandin-endoperoxide synthase 1
- RS10306114 (PTGS1) ??
- RS3842788 (PTGS1) ??
- RS5789 (PTGS1) ??
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Top Gene-Substance Interactions
PTGS1 Interacts with These Diseases
| Disease | Score |
Substances That Increase PTGS1
| Substances | Interaction | Organism | Category |
Substances That Decrease PTGS1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Cofactor:
Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.
Molecular Function:
- Peroxidase Activity
- Prostaglandin-Endoperoxide Synthase Activity
- Lipid Binding
- Heme Binding
- Metal Ion Binding
- Dioxygenase Activity
Biological Processes:
- Prostaglandin Biosynthetic Process
- Lipid Metabolic Process
- Xenobiotic Metabolic Process
- Inflammatory Response
- Response To Oxidative Stress
- Aging
- Learning
- Memory
- Regulation Of Blood Pressure
- Response To Organonitrogen Compound
- Negative Regulation Of Norepinephrine Secretion
- Sensory Perception Of Pain
- Cyclooxygenase Pathway
- Negative Regulation Of Epinephrine Secretion
- Regulation Of Cell Proliferation
- Positive Regulation Of Vasoconstriction
- Positive Regulation Of Smooth Muscle Contraction
- Response To Corticosterone
- Response To Fatty Acid
Drug Bank:
- Acetylsalicylic Acid
- Desmopressin
- Dihomo-Gamma-Linolenic Acid
- Dronabinol
- Icosapent
- Imatinib
- Mesalazine
- Salsalate
- Antipyrine
- Antrafenine
- Bortezomib
- Bromfenac
- Candesartan
- Carprofen
- Chlorpropamide
- Dapsone
- Diazepam
- Diclofenac
- Diethylcarbamazine
- Diflunisal
- Eletriptan
- Eszopiclone
- Etodolac
- Etoposide
- Flurbiprofen
- Hexobarbital
- Hydromorphone
- Ibuprofen
- Ifosfamide
- Indomethacin
- Irbesartan
- Ketobemidone
- Ketoprofen
- Ketorolac
- Lornoxicam
- Lumiracoxib
- Meclofenamic Acid
- Mefenamic Acid
- Meloxicam
- Minoxidil
- Montelukast
- Nabumetone
- Nateglinide
- Nepafenac
- Niflumic Acid
- Nortriptyline
- Oxaprozin
- Pioglitazone
- Piroxicam
- Rosiglitazone
- Salicylic Acid
- Sulfamethoxazole
- Torasemide
- Trisalicylate-Choline
- Sulindac
- Suprofen
- Tenoxicam
- Thalidomide
- Tiaprofenic Acid
- Tolmetin
- Trabectedin
- Valproic Acid
- Voriconazole
- Zafirlukast
- Zileuton
- Zolpidem
- Acetaminophen
- Balsalazide
- Carvedilol
- Diphenhydramine
- Fenoprofen
- Ketamine
- Magnesium Salicylate
- Naproxen
- Phenylbutazone
- Sulfasalazine
- Terbinafine
- Triflusal
- Zopiclone