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  3. PTGS1

PTGS1 (Prostaglandin-endoperoxide synthase 1)

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The Function of PTGS1

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive production of prostanoids in particular in the stomach and platelets. In gastric epithelial cells, it is a key step in the generation of prostaglandins, such as prostaglandin E2 (PGE2), which plays an important role in cytoprotection. In platelets, it is involved in the generation of thromboxane A2 (TXA2), which promotes platelet activation and aggregation, vasoconstriction and proliferation of vascular smooth muscle cells.

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Protein names

Recommended name:

Prostaglandin G/H synthase 1

Short name:

COX-1

Alternative name(s):

Cyclooxygenase-1
Prostaglandin H2 synthase 1
PGH synthase 1
PGHS-1
PHS 1
Prostaglandin-endoperoxide synthase 1

PTGS1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10306114 (PTGS1) ??
  2. RS3842788 (PTGS1) ??
  3. RS5789 (PTGS1) ??

Top Gene-Substance Interactions

PTGS1 Interacts with These Diseases

Disease Score

Substances That Increase PTGS1

Substances Interaction Organism Category

Substances That Decrease PTGS1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AP-1
  • c-Jun
  • Sp1
  • c-Fos

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Arachidonic acid metabolism

Cofactor:

Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.

Molecular Function:

  • Dioxygenase Activity
  • Heme Binding
  • Metal Ion Binding
  • Peroxidase Activity
  • Prostaglandin-Endoperoxide Synthase Activity
  • Lipid Binding

Biological Processes:

  • Cyclooxygenase Pathway
  • Inflammatory Response
  • Lipid Metabolic Process
  • Prostaglandin Biosynthetic Process
  • Regulation Of Blood Pressure
  • Regulation Of Cell Proliferation
  • Response To Oxidative Stress
  • Xenobiotic Metabolic Process
  • Aging
  • Learning
  • Memory
  • Negative Regulation Of Epinephrine Secretion
  • Negative Regulation Of Norepinephrine Secretion
  • Positive Regulation Of Smooth Muscle Contraction
  • Positive Regulation Of Vasoconstriction
  • Response To Corticosterone
  • Response To Fatty Acid
  • Response To Organonitrogen Compound
  • Sensory Perception Of Pain

Drug Bank:

  • Acetylsalicylic Acid
  • Desmopressin
  • Dihomo-Gamma-Linolenic Acid
  • Dronabinol
  • Icosapent
  • Imatinib
  • Mesalazine
  • Salsalate
  • Antipyrine
  • Antrafenine
  • Bortezomib
  • Bromfenac
  • Candesartan
  • Carprofen
  • Chlorpropamide
  • Dapsone
  • Diazepam
  • Diclofenac
  • Diethylcarbamazine
  • Diflunisal
  • Eletriptan
  • Eszopiclone
  • Etodolac
  • Etoposide
  • Flurbiprofen
  • Hexobarbital
  • Hydromorphone
  • Ibuprofen
  • Ifosfamide
  • Indomethacin
  • Irbesartan
  • Ketobemidone
  • Ketoprofen
  • Ketorolac
  • Lornoxicam
  • Lumiracoxib
  • Meclofenamic Acid
  • Mefenamic Acid
  • Meloxicam
  • Minoxidil
  • Montelukast
  • Nabumetone
  • Nateglinide
  • Nepafenac
  • Niflumic Acid
  • Nortriptyline
  • Oxaprozin
  • Pioglitazone
  • Piroxicam
  • Rosiglitazone
  • Salicylic Acid
  • Sulfamethoxazole
  • Torasemide
  • Trisalicylate-Choline
  • Sulindac
  • Suprofen
  • Tenoxicam
  • Thalidomide
  • Tiaprofenic Acid
  • Tolmetin
  • Trabectedin
  • Valproic Acid
  • Voriconazole
  • Zafirlukast
  • Zileuton
  • Zolpidem
  • Acetaminophen
  • Balsalazide
  • Carvedilol
  • Diphenhydramine
  • Fenoprofen
  • Ketamine
  • Magnesium Salicylate
  • Naproxen
  • Phenylbutazone
  • Sulfasalazine
  • Terbinafine
  • Triflusal
  • Zopiclone
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| PCOX1| cox1| A306_13065| AS27_13700| CB1_001164011| COX-1| Cox-1b| COX3| COX-3| cyclooxygenase| cyclooxygenase 1| cyclooxygenase-1| cyclooxygenase 3| D623_10016973| I79_021115| M91_19221| N300_09363| N301_12509| N302_13038| N303_06233| N305_14397| N307_04884| N309_03651| N310_06854| N312_05713| N320_05749| N326_04689| N332_09840| N334_06174| PAL_GLEAN10009783| PANDA_004027| PES-1| PGG/HS| Pghs1| Pghs-1| PGH synthase 1| PHS1| PHS 1| prostaglandin endoperoxide synthase| prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthas| prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)| prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)| Prostaglandin G/H synthase 1| prostaglandin G/H synthase and cyclooxygenase| Prostaglandin H2 synthase 1| prostaglandin H synthase 1| PTGHS| PTGS2| TREES_T100009873| UY3_08174| Y1Q_013281| Y956_02174| Z169_04383| zCOX-1| ptgs1

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