The Function of PTGIS
Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
Protein names
Recommended name:
Prostacyclin synthaseAlternative name(s):
Prostaglandin I2 synthase- RS5628 (PTGIS) ??
- RS5629 (PTGIS) ??
- RS7267348 (PTGIS) ??
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Top Gene-Substance Interactions
PTGIS Interacts with These Diseases
| Disease | Score |
Substances That Increase PTGIS
| Substances | Interaction | Organism | Category |
Substances That Decrease PTGIS
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Essential hypertensionFrom UniProt: Essential hypertension (EHT): A condition in which blood pressure is consistently higher than normal with no identifiable cause. [MIM:145500]
From NCBI Gene: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008] From UniProt: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.
Gene Pathways:
Molecular Function:
- Heme Binding
- Iron Ion Binding
- Monooxygenase Activity
- Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen
- Prostaglandin-I Synthase Activity
Biological Processes:
- Apoptotic Signaling Pathway
- Cellular Response To Hypoxia
- Cellular Response To Interleukin-1
- Cellular Response To Interleukin-6
- Cyclooxygenase Pathway
- Decidualization
- Embryo Implantation
- Icosanoid Metabolic Process
- Negative Regulation Of Inflammatory Response
- Negative Regulation Of Nf-Kappab Transcription Factor Activity
- Negative Regulation Of Nitric Oxide Biosynthetic Process
- Nicotinamide Metabolic Process
- Positive Regulation Of Angiogenesis
- Positive Regulation Of Execution Phase Of Apoptosis
- Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
- Prostaglandin Biosynthetic Process