The Function of PTGIS
Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
Protein names
Recommended name:
Prostacyclin synthaseAlternative name(s):
Prostaglandin I2 synthase- RS5628 (PTGIS) ??
- RS5629 (PTGIS) ??
- RS7267348 (PTGIS) ??
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Top Gene-Substance Interactions
PTGIS Interacts with These Diseases
| Disease | Score |
Substances That Increase PTGIS
| Substances | Interaction | Organism | Category |
Substances That Decrease PTGIS
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Essential hypertensionFrom UniProt: Essential hypertension (EHT): A condition in which blood pressure is consistently higher than normal with no identifiable cause. [MIM:145500]
From NCBI Gene: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008] From UniProt: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.
Gene Pathways:
Molecular Function:
- Monooxygenase Activity
- Iron Ion Binding
- Prostaglandin-I Synthase Activity
- Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen
- Heme Binding
Biological Processes:
- Prostaglandin Biosynthetic Process
- Icosanoid Metabolic Process
- Nicotinamide Metabolic Process
- Embryo Implantation
- Cyclooxygenase Pathway
- Negative Regulation Of Nf-Kappab Transcription Factor Activity
- Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
- Negative Regulation Of Nitric Oxide Biosynthetic Process
- Positive Regulation Of Angiogenesis
- Decidualization
- Negative Regulation Of Inflammatory Response
- Cellular Response To Interleukin-1
- Cellular Response To Interleukin-6
- Cellular Response To Hypoxia
- Apoptotic Signaling Pathway
- Positive Regulation Of Execution Phase Of Apoptosis