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  3. PTGIS

PTGIS (Prostaglandin I2 synthase)

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The Function of PTGIS

Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).

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Protein names

Recommended name:

Prostacyclin synthase

Alternative name(s):

Prostaglandin I2 synthase

PTGIS SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS5628 (PTGIS) ??
  2. RS5629 (PTGIS) ??
  3. RS7267348 (PTGIS) ??

Top Gene-Substance Interactions

PTGIS Interacts with These Diseases

Disease Score

Substances That Increase PTGIS

Substances Interaction Organism Category

Substances That Decrease PTGIS

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Essential hypertensionFrom UniProt: Essential hypertension (EHT): A condition in which blood pressure is consistently higher than normal with no identifiable cause. [MIM:145500]

     From NCBI Gene: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008] From UniProt: Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • AP-1
  • c-Jun
  • NF-kappaB1
  • AREB6

Tissue specificity:

Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.

Gene Pathways:

  • Metabolic pathways
  • Metabolism
  • Disease
  • Arachidonic acid metabolism

Molecular Function:

  • Heme Binding
  • Iron Ion Binding
  • Monooxygenase Activity
  • Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen
  • Prostaglandin-I Synthase Activity

Biological Processes:

  • Apoptotic Signaling Pathway
  • Cellular Response To Hypoxia
  • Cellular Response To Interleukin-1
  • Cellular Response To Interleukin-6
  • Cyclooxygenase Pathway
  • Decidualization
  • Embryo Implantation
  • Icosanoid Metabolic Process
  • Negative Regulation Of Inflammatory Response
  • Negative Regulation Of Nf-Kappab Transcription Factor Activity
  • Negative Regulation Of Nitric Oxide Biosynthetic Process
  • Nicotinamide Metabolic Process
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of Execution Phase Of Apoptosis
  • Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
  • Prostaglandin Biosynthetic Process

Drug Bank:

  • Epoprostenol
  • Phenylbutazone
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| prostacyclin synthase| prostaglandin I2 (prostacyclin) synthase| CYP8| CYP8A1| cytochrome P450 8A1| cytochrome P450, family 8, subfamily A, polypeptide 1| D623_10026384| GW7_14840| H920_02741| M91_17010| MDA_GLEAN10010592| PAL_GLEAN10024458| PANDA_000805| PGIS| prostacyclin synthase-like protein| prostaglandin I2 (prostacyclin) synthase like| PTGI| ptgisl| UY3_06990| ptgis

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