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  3. PTGES2

PTGES2 (Prostaglandin E synthase 2)

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The Function of PTGES2

Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2).

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Protein names

Recommended name:

Prostaglandin E synthase 2

Alternative name(s):

Membrane-associated prostaglandin E synthase-2
mPGE synthase-2
Microsomal prostaglandin E synthase 2
mPGES-2
Prostaglandin-H(2

PTGES2 SNPs

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  1. RS13283456 (PTGES2) ??
  2. RS884115 (PTGES2) ??

Top Gene-Substance Interactions

Substances That Increase PTGES2

Substances Interaction Organism Category

Substances That Decrease PTGES2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • HNF-1A
  • PPAR-gamma2
  • STAT3
  • HNF-1
  • C/EBPalpha
  • c-Myc
  • Nkx5-1

Tissue specificity:

Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.

Gene Pathways:

  • Metabolic pathways
  • Arachidonic acid metabolism

Caution:

Heme and GST are not required for prostaglandin synthase activity, but the protein copurifies with heme and GST when DTT is omitted during the purification procedure. The GSH-heme complex-bound enzyme (mPGES-2h) has been proposed to act as a lyase and catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA), but this activity may well be spurious. According to PubMed:18198127, boiling the enzyme leads to loss of prostaglandin synthase activity, but does not eliminate the lyase activity. Besides, free heme can catalyze the formation of 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT).

Enzyme Regulation:

Isomerase activity is increased by sulfhydril compounds. Dithiothreitol (DTT) is most effective, followed by dihydrolipoic acid, glutathione (GSH) and 2-mercaptoethanol.

Molecular Function:

  • Dna Binding
  • Electron Carrier Activity
  • Glutathione Binding
  • Heme Binding
  • Lyase Activity
  • Prostaglandin-E Synthase Activity
  • Protein Disulfide Oxidoreductase Activity

Biological Processes:

  • Cell Redox Homeostasis
  • Positive Regulation Of Transcription, Dna-Templated
  • Prostaglandin Biosynthetic Process
  • Secretion
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| gbf1| Anapl_04335| AS27_01565| AS28_01193| C79137| C9orf15| CB1_000576027| D623_10025025| gamma-interferon-activated transcriptional element-binding factor 1| GATE-binding factor 1| GBF-1| H920_19196| I79_014770| M91_12705| M959_12051| MDA_GLEAN10019304| membrane-associated prostaglandin E synthase 2| membrane-associated prostaglandin E synthase-2| microsomal prostaglandin E synthase 2| microsomal prostaglandin E synthase-2| Mpges2| MPGES-2| mPGE synthase-2| N300_09271| N301_12743| N302_13172| N303_06092| N305_09010| N306_14810| N307_02442| N308_10508| N311_11677| N312_00533| N320_07005| N321_11509| N322_00413| N324_09565| N325_00199| N326_00389| N327_11175| N328_09700| N329_10988| N330_00570| N331_03110| N332_07603| N333_00239| N334_00603| N335_09322| N336_03658| N339_06101| N340_07113| N341_11017| PAL_GLEAN10012478| PANDA_003194| pges2| prostaglandin E receptor 2| prostaglandin E synthase 2-like protein| prostaglandin-H(2) E-isomerase| TREES_T100004307| UY3_04702| Y1Q_013357| Y956_02025| Z169_03807| ptges2

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