The following transcription factors affect gene expression:

• PPAR-gamma1
• HNF-1A
• PPAR-gamma2
• STAT3
• HNF-1
• C/EBPalpha
• c-Myc
• Nkx5-1

Tissue specificity:

Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.

Caution:

Heme and GST are not required for prostaglandin synthase activity, but the protein copurifies with heme and GST when DTT is omitted during the purification procedure. The GSH-heme complex-bound enzyme (mPGES-2h) has been proposed to act as a lyase and catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA), but this activity may well be spurious. According to PubMed:18198127, boiling the enzyme leads to loss of prostaglandin synthase activity, but does not eliminate the lyase activity. Besides, free heme can catalyze the formation of 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT).

Enzyme Regulation:

Isomerase activity is increased by sulfhydril compounds. Dithiothreitol (DTT) is most effective, followed by dihydrolipoic acid, glutathione (GSH) and 2-mercaptoethanol.

Molecular Function:

• Dna Binding
• Electron Carrier Activity
• Protein Disulfide Oxidoreductase Activity
• Lyase Activity
• Heme Binding
• Glutathione Binding
• Prostaglandin-E Synthase Activity

Biological Processes:

• Prostaglandin Biosynthetic Process
• Cell Redox Homeostasis
• Positive Regulation Of Transcription, Dna-Templated
• Secretion