The Function of PTGES2
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2).
Protein names
Recommended name:
Prostaglandin E synthase 2Alternative name(s):
Membrane-associated prostaglandin E synthase-2mPGE synthase-2
Microsomal prostaglandin E synthase 2
mPGES-2
Prostaglandin-H(2
- RS13283456 (PTGES2) ??
- RS884115 (PTGES2) ??
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Top Gene-Substance Interactions
Substances That Increase PTGES2
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Substances That Decrease PTGES2
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Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer.
Gene Pathways:
Caution:
Heme and GST are not required for prostaglandin synthase activity, but the protein copurifies with heme and GST when DTT is omitted during the purification procedure. The GSH-heme complex-bound enzyme (mPGES-2h) has been proposed to act as a lyase and catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA), but this activity may well be spurious. According to PubMed:18198127, boiling the enzyme leads to loss of prostaglandin synthase activity, but does not eliminate the lyase activity. Besides, free heme can catalyze the formation of 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT).
Enzyme Regulation:
Isomerase activity is increased by sulfhydril compounds. Dithiothreitol (DTT) is most effective, followed by dihydrolipoic acid, glutathione (GSH) and 2-mercaptoethanol.
Molecular Function:
- Dna Binding
- Electron Carrier Activity
- Glutathione Binding
- Heme Binding
- Lyase Activity
- Prostaglandin-E Synthase Activity
- Protein Disulfide Oxidoreductase Activity
Biological Processes:
- Cell Redox Homeostasis
- Positive Regulation Of Transcription, Dna-Templated
- Prostaglandin Biosynthetic Process
- Secretion