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  3. PTGER4

PTGER4 (Prostaglandin E receptor 4)

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The Function of PTGER4

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.

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Protein names

Recommended name:

Prostaglandin E2 receptor EP4 subtype

Alternative name(s):

PGE receptor EP4 subtype
PGE2 receptor EP4 subtype
Prostanoid EP4 receptor

PTGER4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10036575 (PTGER4) ??
  2. RS1992660 (PTGER4) ??
  3. RS1992662 (PTGER4) ??
  4. RS7720838 (PTGER4) ??
  5. RS7725052 (PTGER4) ??

Top Gene-Substance Interactions

PTGER4 Interacts with These Diseases

Disease Score

Substances That Increase PTGER4

Substances Interaction Organism Category

Substances That Decrease PTGER4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • PPAR-alpha
  • C/EBPalpha
  • p300

Tissue specificity:

High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction

Caution:

Was originally designated as the EP2 subtype.

Molecular Function:

  • Prostaglandin E Receptor Activity

Biological Processes:

  • Adenylate Cyclase-Activating G-Protein Coupled Receptor Signaling Pathway
  • Adenylate Cyclase-Modulating G-Protein Coupled Receptor Signaling Pathway
  • Bone Development
  • Cellular Response To Mechanical Stimulus
  • Cellular Response To Prostaglandin E Stimulus
  • Erk1 And Erk2 Cascade
  • Immune Response
  • Jnk Cascade
  • Negative Regulation Of Cytokine Secretion
  • Negative Regulation Of Eosinophil Extravasation
  • Negative Regulation Of Inflammatory Response
  • Negative Regulation Of Integrin Activation
  • Positive Regulation Of Cytokine Secretion
  • Positive Regulation Of Cytosolic Calcium Ion Concentration
  • Positive Regulation Of Inflammatory Response
  • Regulation Of Ossification
  • Regulation Of Stress Fiber Assembly
  • Response To Lipopolysaccharide
  • Response To Mechanical Stimulus
  • T-Helper Cell Differentiation
  • Cellular Response To Glucose Stimulus
  • Cellular Response To Interleukin-1
  • Chemokinesis
  • Ductus Arteriosus Closure
  • Female Pregnancy
  • Maternal Process Involved In Parturition
  • Negative Regulation Of Circadian Sleep/Wake Cycle, Rem Sleep
  • Negative Regulation Of Ductus Arteriosus Closure
  • Negative Regulation Of Endothelin Secretion
  • Negative Regulation Of Hydrogen Peroxide Metabolic Process
  • Negative Regulation Of Interleukin-1 Alpha Secretion
  • Negative Regulation Of Nitric-Oxide Synthase Biosynthetic Process
  • Negative Regulation Of Peptide Secretion
  • Negative Regulation Of Small Intestine Smooth Muscle Contraction
  • Negative Regulation Of Tumor Necrosis Factor Secretion
  • Positive Regulation Of Antral Ovarian Follicle Growth
  • Positive Regulation Of Bone Resorption
  • Positive Regulation Of Calcitonin Secretion
  • Positive Regulation Of Camp Biosynthetic Process
  • Positive Regulation Of Cell Adhesion
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Chemokinesis
  • Positive Regulation Of Circadian Sleep/Wake Cycle, Non-Rem Sleep
  • Positive Regulation Of Gene Expression
  • Positive Regulation Of Hyaluronan Biosynthetic Process
  • Positive Regulation Of Interleukin-10 Secretion
  • Positive Regulation Of Interleukin-8 Production
  • Positive Regulation Of Matrix Metallopeptidase Secretion
  • Positive Regulation Of Mucus Secretion
  • Positive Regulation Of Neutrophil Extravasation
  • Positive Regulation Of Osteoblast Differentiation
  • Positive Regulation Of Renal Sodium Excretion
  • Positive Regulation Of Smooth Muscle Cell Migration
  • Positive Regulation Of Substance P Secretion, Neurotransmission
  • Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
  • Positive Regulation Of Urine Volume
  • Positive Regulation Of Wound Healing
  • Regulation Of Circadian Sleep/Wake Cycle, Wakefulness
  • Response To Amino Acid
  • Response To Progesterone
  • Response To Salt
  • Response To Water-Immersion Restraint Stress

Drug Bank:

  • Misoprostol
  • Dinoprostone
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_06552| AS27_01104| AS28_11255| CB1_001954002| D623_10012280| EH28_20278| EP4| EP4b| EP4R| GW7_08761| H920_09435| I79_010073| M959_07433| N300_07421| N301_10864| N302_10527| N303_04217| N305_02229| N306_15480| N307_10485| N308_09903| N310_00141| N311_09119| N312_10149| N320_10876| N322_09087| N324_00748| N325_11396| N332_09007| N339_01242| PAL_GLEAN10006170| PANDA_011643| PGE2 receptor EP4 subtype| PGE2R-EP4| PGE receptor EP4 subtype| PGE receptor, EP4 subtype| PGE receptor, subtype EP4| prostaglandin E2 receptor 4| Prostaglandin E2 receptor EP4 subtype| prostaglandin E2 receptor subtype 4| prostaglandin E2 receptor type 4| prostaglandin E2 subtype EP4 receptor| prostaglandin E receptor 4b| prostaglandin E receptor 4 (subtype EP4)| prostaglandin receptor EP4 subtype| prostanoid EP4 receptor| Ptger| PTGER4b| Ptgerep4| TREES_T100020838| UY3_12592| Y1Q_007148| Z169_13334| ptger4

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