The Function of PTGER4
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
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Protein names
Recommended name:
Prostaglandin E2 receptor EP4 subtypeAlternative name(s):
PGE receptor EP4 subtypePGE2 receptor EP4 subtype
Prostanoid EP4 receptor
- RS10036575 (PTGER4) ??
- RS1992660 (PTGER4) ??
- RS1992662 (PTGER4) ??
- RS7720838 (PTGER4) ??
- RS7725052 (PTGER4) ??
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Top Gene-Substance Interactions
PTGER4 Interacts with These Diseases
| Disease | Score |
Substances That Increase PTGER4
| Substances | Interaction | Organism | Category |
Substances That Decrease PTGER4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.
Gene Pathways:
Caution:
Was originally designated as the EP2 subtype.
Molecular Function:
Biological Processes:
- Adenylate Cyclase-Activating G-Protein Coupled Receptor Signaling Pathway
- Adenylate Cyclase-Modulating G-Protein Coupled Receptor Signaling Pathway
- Bone Development
- Cellular Response To Mechanical Stimulus
- Cellular Response To Prostaglandin E Stimulus
- Erk1 And Erk2 Cascade
- Immune Response
- Jnk Cascade
- Negative Regulation Of Cytokine Secretion
- Negative Regulation Of Eosinophil Extravasation
- Negative Regulation Of Inflammatory Response
- Negative Regulation Of Integrin Activation
- Positive Regulation Of Cytokine Secretion
- Positive Regulation Of Cytosolic Calcium Ion Concentration
- Positive Regulation Of Inflammatory Response
- Regulation Of Ossification
- Regulation Of Stress Fiber Assembly
- Response To Lipopolysaccharide
- Response To Mechanical Stimulus
- T-Helper Cell Differentiation
- Cellular Response To Glucose Stimulus
- Cellular Response To Interleukin-1
- Chemokinesis
- Ductus Arteriosus Closure
- Female Pregnancy
- Maternal Process Involved In Parturition
- Negative Regulation Of Circadian Sleep/Wake Cycle, Rem Sleep
- Negative Regulation Of Ductus Arteriosus Closure
- Negative Regulation Of Endothelin Secretion
- Negative Regulation Of Hydrogen Peroxide Metabolic Process
- Negative Regulation Of Interleukin-1 Alpha Secretion
- Negative Regulation Of Nitric-Oxide Synthase Biosynthetic Process
- Negative Regulation Of Peptide Secretion
- Negative Regulation Of Small Intestine Smooth Muscle Contraction
- Negative Regulation Of Tumor Necrosis Factor Secretion
- Positive Regulation Of Antral Ovarian Follicle Growth
- Positive Regulation Of Bone Resorption
- Positive Regulation Of Calcitonin Secretion
- Positive Regulation Of Camp Biosynthetic Process
- Positive Regulation Of Cell Adhesion
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Chemokinesis
- Positive Regulation Of Circadian Sleep/Wake Cycle, Non-Rem Sleep
- Positive Regulation Of Gene Expression
- Positive Regulation Of Hyaluronan Biosynthetic Process
- Positive Regulation Of Interleukin-10 Secretion
- Positive Regulation Of Interleukin-8 Production
- Positive Regulation Of Matrix Metallopeptidase Secretion
- Positive Regulation Of Mucus Secretion
- Positive Regulation Of Neutrophil Extravasation
- Positive Regulation Of Osteoblast Differentiation
- Positive Regulation Of Renal Sodium Excretion
- Positive Regulation Of Smooth Muscle Cell Migration
- Positive Regulation Of Substance P Secretion, Neurotransmission
- Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
- Positive Regulation Of Urine Volume
- Positive Regulation Of Wound Healing
- Regulation Of Circadian Sleep/Wake Cycle, Wakefulness
- Response To Amino Acid
- Response To Progesterone
- Response To Salt
- Response To Water-Immersion Restraint Stress