The Function of PSMB10
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.
Protein names
Recommended name:
Proteasome subunit beta type-10Alternative name(s):
Low molecular mass protein 10Macropain subunit MECl-1
Multicatalytic endopeptidase complex subunit MECl-1
Proteasome MECl-1
Proteasome subunit beta-2i
- RS11574514 (PSMB10) ??
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Top Gene-Substance Interactions
Substances That Increase PSMB10
| Substances | Interaction | Organism | Category |
Substances That Decrease PSMB10
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Induction:
Up-regulated by IFNG/IFN-gamma (at protein level). Up-regulated by IRF1. Up-regulated by TNF (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohn's bowel disease (CD). Up-regulated by CD40L via the NFKB1 pathway in cancer cells.
Developmental stage:
Highly expressed in immature dendritic cells (at protein level).
Molecular Function:
Biological Processes:
- Anaphase-Promoting Complex-Dependent Catabolic Process
- Antigen Processing And Presentation Of Exogenous Peptide Antigen Via Mhc Class I, Tap-Dependent
- Fc-Epsilon Receptor Signaling Pathway
- Humoral Immune Response
- Mapk Cascade
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Negative Regulation Of Ubiquitin-Protein Ligase Activity Involved In Mitotic Cell Cycle
- Nik/Nf-Kappab Signaling
- Positive Regulation Of Canonical Wnt Signaling Pathway
- Positive Regulation Of Ubiquitin-Protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
- Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
- Protein Polyubiquitination
- Regulation Of Cellular Amino Acid Metabolic Process
- Regulation Of Mrna Stability
- Stimulatory C-Type Lectin Receptor Signaling Pathway
- T Cell Receptor Signaling Pathway
- Tumor Necrosis Factor-Mediated Signaling Pathway
- Viral Process
- Wnt Signaling Pathway, Planar Cell Polarity Pathway
- Cell Morphogenesis
- T Cell Proliferation