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  3. PSMB10

PSMB10 (Proteasome subunit beta 10)

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The Function of PSMB10

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.

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Protein names

Recommended name:

Proteasome subunit beta type-10

Alternative name(s):

Low molecular mass protein 10
Macropain subunit MECl-1
Multicatalytic endopeptidase complex subunit MECl-1
Proteasome MECl-1
Proteasome subunit beta-2i

PSMB10 SNPs

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  1. RS11574514 (PSMB10) ??

Top Gene-Substance Interactions

Substances That Increase PSMB10

Substances Interaction Organism Category

Substances That Decrease PSMB10

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

Gene Pathways:

  • Metabolism
  • Disease
  • Immune System
  • Signal Transduction
  • Gene Expression
  • Apoptosis
  • DNA Replication
  • Metabolism of RNA
  • Proteasome
  • Cdc20:Phospho-APC/C mediated degradation of Cyclin A
  • Glycerophospholipid metabolism

Induction:

Up-regulated by IFNG/IFN-gamma (at protein level). Up-regulated by IRF1. Up-regulated by TNF (at protein level). Up-regulated by tetrodotoxin (TTX) in glial cells. Up-regulated in Crohn's bowel disease (CD). Up-regulated by CD40L via the NFKB1 pathway in cancer cells.

Developmental stage:

Highly expressed in immature dendritic cells (at protein level).

Molecular Function:

  • Threonine-Type Endopeptidase Activity

Biological Processes:

  • Anaphase-Promoting Complex-Dependent Catabolic Process
  • Antigen Processing And Presentation Of Exogenous Peptide Antigen Via Mhc Class I, Tap-Dependent
  • Fc-Epsilon Receptor Signaling Pathway
  • Humoral Immune Response
  • Mapk Cascade
  • Negative Regulation Of Canonical Wnt Signaling Pathway
  • Negative Regulation Of Ubiquitin-Protein Ligase Activity Involved In Mitotic Cell Cycle
  • Nik/Nf-Kappab Signaling
  • Positive Regulation Of Canonical Wnt Signaling Pathway
  • Positive Regulation Of Ubiquitin-Protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
  • Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
  • Protein Polyubiquitination
  • Regulation Of Cellular Amino Acid Metabolic Process
  • Regulation Of Mrna Stability
  • Stimulatory C-Type Lectin Receptor Signaling Pathway
  • T Cell Receptor Signaling Pathway
  • Tumor Necrosis Factor-Mediated Signaling Pathway
  • Viral Process
  • Wnt Signaling Pathway, Planar Cell Polarity Pathway
  • Cell Morphogenesis
  • T Cell Proliferation

Drug Bank:

  • Carfilzomib
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

beta2i| D623_10015093| GW7_02377| H920_18633| LMP10| low molecular mass protein 10| macropain| macropain subunit MECl-1| MDA_GLEAN10017081| Mecl-1| MECL1| multicatalytic endopeptidase complex subunit MECl-1| PAL_GLEAN10016251| PANDA_006958| prosome| prosome Mecl1| proteasome beta 10 subunit| proteasome catalytic subunit 2i| proteasome MECl-1| proteasome (prosome, macropain) subunit, beta type 10| proteasome (prosome, macropain) subunit, beta type, 10| proteasome (prosome, macropain) subunit, beta type, 12| proteasome (prosomome, macropain) subunit, beta type 10| proteasome subunit 10| proteasome subunit beta-2i| proteasome subunit beta 7i| proteasome subunit, beta type 10| Proteasome subunit beta type-10| proteasome subunit MECL1| psmb12| psmb10

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