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  3. PSCA

PSCA (Prostate stem cell antigen)

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The Function of PSCA

May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.

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Protein names

Recommended name:

Prostate stem cell antigen

PSCA SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12155758 (PSCA) ??
  2. RS2294008 (PSCA) ??
  3. RS2976392 (PSCA) ??
  4. RS72690918 (PSCA) ??

Top Gene-Substance Interactions

PSCA Interacts with These Diseases

Disease Score

Substances That Increase PSCA

Substances Interaction Organism Category

Substances That Decrease PSCA

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • c-Myc
  • Nkx3-1 v1
  • Nkx3-1

Tissue specificity:

Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level).

Induction:

Down-regulated in gastric cancer cells.

Caution:

The start codon presents some polymorphism and the initiation methionine is a threonine on the genome.

*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| GW7_10506| H920_11790| I79_020048| M959_06874| N303_13867| N306_10954| N310_11227| N325_04483| N328_05345| N330_00884| N331_01717| N332_03778| PAL_GLEAN10010419| PANDA_010554| PRO232| prostate stem cell antigen-like protein| TREES_T100016018| Y956_13280| psca

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