The Function of PSCA
May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.
Protein names
Recommended name:
Prostate stem cell antigen- RS12155758 (PSCA) ??
- RS2294008 (PSCA) ??
- RS2976392 (PSCA) ??
- RS72690918 (PSCA) ??
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Top Gene-Substance Interactions
PSCA Interacts with These Diseases
| Disease | Score |
Substances That Increase PSCA
| Substances | Interaction | Organism | Category |
Substances That Decrease PSCA
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level).
Induction:
Down-regulated in gastric cancer cells.
Caution:
The start codon presents some polymorphism and the initiation methionine is a threonine on the genome.
*synonyms