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  3. PRUNE2

PRUNE2 (Prune homolog 2)

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The Function of PRUNE2

May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells.

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Protein names

Recommended name:

Protein prune homolog 2

Alternative name(s):

BNIP2 motif-containing molecule at the C-terminal region 1

PRUNE2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10781380 (PRUNE2) ??

Top Gene-Substance Interactions

Substances That Increase PRUNE2

Substances Interaction Organism Category

Substances That Decrease PRUNE2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • E2F-1
  • E2F-4
  • E2F-5
  • NF-E2

Tissue specificity:

A high level of expression seen in the nervous system (brain, cerebellum and spinal cord) as well as adrenal gland. Expressed at high levels in noneuroblastoma, rhabdomyosarcoma, melanoma and some osteosarcoma cell lines, whereas at only low levels in cancer cell lines of liver, breast, thyroid and colon. Expression is significantly higher in favorable tumors than aggressive ones.

Induction:

Down-regulated after NGF-induced differentiation, and up-regulated during the NGF-depletion-induced apoptosis.

Developmental stage:

Induced during the G1 phase of the cell cycle.

Molecular Function:

  • Metal Ion Binding
  • Pyrophosphatase Activity

Biological Processes:

  • Apoptotic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Protein prune 2| neuronal protein| A306_07276| AS27_02931| AS28_10944| BCH motif-containing molecule at the carboxyl terminal region 1| bmcc1| BNIP2 motif-containing molecule| BNIP2 motif containing molecule at the carboxyl terminal region 1| BNIP2 motif containing molecule at the carboxyl terminal region 1-like protein| BNIP2 motif-containing molecule at the C-terminal region 1| BNIPXL| C9orf65| CB1_001144019| D623_10034405| H920_00665| I79_019527| KIAA0367| M91_05523| M959_07786| MDA_GLEAN10017418| N300_09220| N301_12794| N302_08921| N303_05275| N305_03719| N306_02627| N307_10002| N308_04124| N309_07912| N310_11315| N311_05657| N312_11330| N320_04712| N321_00585| N322_10700| N324_06550| N325_02077| N327_04743| N329_12557| N330_04966| N331_07353| N332_02894| N333_00073| N334_14432| N335_01055| N336_01751| N341_13014| olfaxin| PANDA_013890| protein prune homolog 2| Protein prune-like 2| protein prune-like protein| Protein prune like protein 2| Protein prune-like protein 2| prune homolog 2 (Drosophila)| prune-like protein 2| RGD1311350| TREES_T100013054| truncated PRUNE2| UY3_12420| Y1Q_011106| Y956_14669| Z169_03356| prune2

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