The Function of PRUNE2
May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells.
Protein names
Recommended name:
Protein prune homolog 2Alternative name(s):
BNIP2 motif-containing molecule at the C-terminal region 1- RS10781380 (PRUNE2) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
Substances That Increase PRUNE2
| Substances | Interaction | Organism | Category |
Substances That Decrease PRUNE2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
A high level of expression seen in the nervous system (brain, cerebellum and spinal cord) as well as adrenal gland. Expressed at high levels in noneuroblastoma, rhabdomyosarcoma, melanoma and some osteosarcoma cell lines, whereas at only low levels in cancer cell lines of liver, breast, thyroid and colon. Expression is significantly higher in favorable tumors than aggressive ones.
Induction:
Down-regulated after NGF-induced differentiation, and up-regulated during the NGF-depletion-induced apoptosis.
Developmental stage:
Induced during the G1 phase of the cell cycle.