The Function of PROX1
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
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Protein names
Recommended name:
Prospero homeobox protein 1Short name:
PROX-1Alternative name(s):
Homeobox prospero-like protein PROX1- RS340839 (PROX1) ??
- RS340874 (PROX1) ??
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Top Gene-Substance Interactions
PROX1 Interacts with These Diseases
| Disease | Score |
Substances That Increase PROX1
| Substances | Interaction | Organism | Category |
Substances That Decrease PROX1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
Molecular Function:
- Core Promoter Sequence-Specific Dna Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Transcription Corepressor Activity
- Ligand-Dependent Nuclear Receptor Binding
- Transcription Regulatory Region Dna Binding
- Dbd Domain Binding
- Lbd Domain Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Cell Fate Determination
- Kidney Development
- Liver Development
- Positive Regulation Of Endothelial Cell Proliferation
- Lymphangiogenesis
- Lens Development In Camera-Type Eye
- Hepatocyte Cell Migration
- Transcription, Dna-Templated
- Brain Development
- Circadian Rhythm
- Positive Regulation Of Cell Proliferation
- Negative Regulation Of Cell Proliferation
- Regulation Of Gene Expression
- Positive Regulation Of Endothelial Cell Migration
- Dorsal Spinal Cord Development
- Dentate Gyrus Development
- Cerebellar Granule Cell Differentiation
- Neural Tube Development
- Neuron Differentiation
- Skeletal Muscle Thin Filament Assembly
- Lung Development
- Olfactory Placode Formation
- Pancreas Development
- Response To Nutrient Levels
- Regulation Of Circadian Rhythm
- Otic Placode Formation
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Negative Regulation Of Viral Genome Replication
- Positive Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
- Positive Regulation Of Cell Cycle
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Optic Placode Formation Involved In Camera-Type Eye Formation
- Venous Blood Vessel Morphogenesis
- Ventricular Cardiac Myofibril Assembly
- Cardiac Muscle Cell Differentiation
- Atrial Cardiac Muscle Tissue Morphogenesis
- Ventricular Cardiac Muscle Tissue Morphogenesis
- Retina Morphogenesis In Camera-Type Eye
- Embryonic Retina Morphogenesis In Camera-Type Eye
- Endocardium Formation
- Positive Regulation Of Sarcomere Organization
- Ventricular Septum Morphogenesis
- Aorta Smooth Muscle Tissue Morphogenesis
- Positive Regulation Of Heart Growth
- Lymphatic Endothelial Cell Differentiation
- Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment
- Branching Involved In Pancreas Morphogenesis
- Lens Fiber Cell Morphogenesis
- Hepatocyte Differentiation
- Negative Regulation Of Bile Acid Biosynthetic Process
- Hepatocyte Proliferation
- Acinar Cell Differentiation
- Neuronal Stem Cell Population Maintenance
- Positive Regulation Of Cell Cycle Checkpoint
- Positive Regulation Of Neural Precursor Cell Proliferation
- Positive Regulation Of Forebrain Neuron Differentiation