The Function of PROX1
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.
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Protein names
Recommended name:
Prospero homeobox protein 1Short name:
PROX-1Alternative name(s):
Homeobox prospero-like protein PROX1- RS340839 (PROX1) ??
- RS340874 (PROX1) ??
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Top Gene-Substance Interactions
PROX1 Interacts with These Diseases
| Disease | Score |
Substances That Increase PROX1
| Substances | Interaction | Organism | Category |
Substances That Decrease PROX1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
Molecular Function:
- Core Promoter Sequence-Specific Dna Binding
- Dbd Domain Binding
- Dna Binding
- Lbd Domain Binding
- Ligand-Dependent Nuclear Receptor Binding
- Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcription Corepressor Activity
- Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Regulatory Region Dna Binding
Biological Processes:
- Acinar Cell Differentiation
- Aorta Smooth Muscle Tissue Morphogenesis
- Atrial Cardiac Muscle Tissue Morphogenesis
- Brain Development
- Branching Involved In Pancreas Morphogenesis
- Cardiac Muscle Cell Differentiation
- Cell Fate Determination
- Cerebellar Granule Cell Differentiation
- Circadian Rhythm
- Dentate Gyrus Development
- Dorsal Spinal Cord Development
- Embryonic Retina Morphogenesis In Camera-Type Eye
- Endocardium Formation
- Hepatocyte Cell Migration
- Hepatocyte Differentiation
- Hepatocyte Proliferation
- Kidney Development
- Lens Development In Camera-Type Eye
- Lens Fiber Cell Morphogenesis
- Liver Development
- Lung Development
- Lymphangiogenesis
- Lymphatic Endothelial Cell Differentiation
- Negative Regulation Of Bile Acid Biosynthetic Process
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Negative Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Negative Regulation Of Viral Genome Replication
- Neural Tube Development
- Neuronal Stem Cell Population Maintenance
- Neuron Differentiation
- Olfactory Placode Formation
- Optic Placode Formation Involved In Camera-Type Eye Formation
- Otic Placode Formation
- Pancreas Development
- Positive Regulation Of Cell Cycle
- Positive Regulation Of Cell Cycle Checkpoint
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
- Positive Regulation Of Endothelial Cell Migration
- Positive Regulation Of Endothelial Cell Proliferation
- Positive Regulation Of Forebrain Neuron Differentiation
- Positive Regulation Of Heart Growth
- Positive Regulation Of Neural Precursor Cell Proliferation
- Positive Regulation Of Sarcomere Organization
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Circadian Rhythm
- Regulation Of Gene Expression
- Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment
- Response To Nutrient Levels
- Retina Morphogenesis In Camera-Type Eye
- Skeletal Muscle Thin Filament Assembly
- Transcription, Dna-Templated
- Venous Blood Vessel Morphogenesis
- Ventricular Cardiac Muscle Tissue Morphogenesis
- Ventricular Cardiac Myofibril Assembly
- Ventricular Septum Morphogenesis