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  3. PROX1

PROX1 (Prospero homeobox 1)

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The Function of PROX1

Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.

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Protein names

Recommended name:

Prospero homeobox protein 1

Short name:

PROX-1

Alternative name(s):

Homeobox prospero-like protein PROX1

PROX1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS340839 (PROX1) ??
  2. RS340874 (PROX1) ??

Top Gene-Substance Interactions

PROX1 Interacts with These Diseases

Disease Score

Substances That Increase PROX1

Substances Interaction Organism Category

Substances That Decrease PROX1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Pax-6
  • HNF-4alpha1
  • HNF-4alpha2
  • Nkx2-2
  • HSF2

Tissue specificity:

Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.

Molecular Function:

  • Core Promoter Sequence-Specific Dna Binding
  • Dbd Domain Binding
  • Dna Binding
  • Lbd Domain Binding
  • Ligand-Dependent Nuclear Receptor Binding
  • Transcriptional Repressor Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
  • Transcription Corepressor Activity
  • Transcription Factor Activity, Rna Polymerase Ii Distal Enhancer Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding
  • Transcription Regulatory Region Dna Binding

Biological Processes:

  • Acinar Cell Differentiation
  • Aorta Smooth Muscle Tissue Morphogenesis
  • Atrial Cardiac Muscle Tissue Morphogenesis
  • Brain Development
  • Branching Involved In Pancreas Morphogenesis
  • Cardiac Muscle Cell Differentiation
  • Cell Fate Determination
  • Cerebellar Granule Cell Differentiation
  • Circadian Rhythm
  • Dentate Gyrus Development
  • Dorsal Spinal Cord Development
  • Embryonic Retina Morphogenesis In Camera-Type Eye
  • Endocardium Formation
  • Hepatocyte Cell Migration
  • Hepatocyte Differentiation
  • Hepatocyte Proliferation
  • Kidney Development
  • Lens Development In Camera-Type Eye
  • Lens Fiber Cell Morphogenesis
  • Liver Development
  • Lung Development
  • Lymphangiogenesis
  • Lymphatic Endothelial Cell Differentiation
  • Negative Regulation Of Bile Acid Biosynthetic Process
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Negative Regulation Of Transcription, Dna-Templated
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Negative Regulation Of Viral Genome Replication
  • Neural Tube Development
  • Neuronal Stem Cell Population Maintenance
  • Neuron Differentiation
  • Olfactory Placode Formation
  • Optic Placode Formation Involved In Camera-Type Eye Formation
  • Otic Placode Formation
  • Pancreas Development
  • Positive Regulation Of Cell Cycle
  • Positive Regulation Of Cell Cycle Checkpoint
  • Positive Regulation Of Cell Proliferation
  • Positive Regulation Of Cyclin-Dependent Protein Serine/Threonine Kinase Activity
  • Positive Regulation Of Endothelial Cell Migration
  • Positive Regulation Of Endothelial Cell Proliferation
  • Positive Regulation Of Forebrain Neuron Differentiation
  • Positive Regulation Of Heart Growth
  • Positive Regulation Of Neural Precursor Cell Proliferation
  • Positive Regulation Of Sarcomere Organization
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Circadian Rhythm
  • Regulation Of Gene Expression
  • Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment
  • Response To Nutrient Levels
  • Retina Morphogenesis In Camera-Type Eye
  • Skeletal Muscle Thin Filament Assembly
  • Transcription, Dna-Templated
  • Venous Blood Vessel Morphogenesis
  • Ventricular Cardiac Muscle Tissue Morphogenesis
  • Ventricular Cardiac Myofibril Assembly
  • Ventricular Septum Morphogenesis
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_00905| AS27_04691| AS28_07626| CB1_000818003| D623_10018243| EGK_01663| GW7_11983| H920_13181| homeobox prospero-like protein PROX1| homeobox transcription factor Prox1| I79_000110| M91_05912| M959_04484| MDA_GLEAN10017461| N300_11443| N301_08614| N302_00719| N303_07618| N306_11609| N307_14758| N308_02457| N309_08325| N310_09587| N311_03080| N320_01845| N324_06646| N330_10960| N331_06804| N332_06392| N333_03814| N334_09668| N335_05080| N339_09669| N341_02878| PAL_GLEAN10017636| PANDA_009835| prospero| Prospero homeobox protein 1| prospero-related homeobox 1| prospero-related homeobox protein 1a| Prox 1| PROX-1| prox1a| TREES_T100017243| UY3_11703| xprox1| Y1Q_017411| Y956_07727| Z169_07530| prox1

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