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  3. PROCR

PROCR (Protein C receptor)

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The Function of PROCR

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

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Protein names

Recommended name:

Endothelial protein C receptor

Alternative name(s):

Activated protein C receptor
APC receptor
Endothelial cell protein C receptor
CD antigen CD201

PROCR SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11167260 (PROCR) ??
  2. RS17310467 (PROCR) ??
  3. RS6060278 (PROCR) ??
  4. RS6087685 (PROCR) ??
  5. RS6088735 (PROCR) ??
  6. RS6088765 (PROCR) ??
  7. RS8114671 (PROCR) ??
  8. RS867186 (PROCR) ??
  9. RS9574 (PROCR) ??

Top Gene-Substance Interactions

PROCR Interacts with These Diseases

Disease Score

Substances That Increase PROCR

Substances Interaction Organism Category

Substances That Decrease PROCR

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • c-Jun
  • c-Fos
  • FAC1
  • Nkx3-1 v1
  • Nkx3-1

Tissue specificity:

Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.

Molecular Function:

  • Receptor Activity

Biological Processes:

  • Blood Coagulation
  • Leukocyte Migration
  • Negative Regulation Of Coagulation
  • Immune Response

Drug Bank:

  • Drotrecogin Alfa
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| activated protein C receptor| APC receptor| AS27_13652| CB1_001108021| CCCA| CCD41| CD201 antigen| CD antigen CD201| cell cycle, centrosome-associated protein| centrocyclin| centrosomal protein CCD41| EGK_02471| endothelial cell protein C/activated protein C| endothelial cell protein C receptor| Endothelial protein C receptor| endothelial protein C receptor-like protein| Epcr| GW7_21539| M91_20156| MDA_GLEAN10022754| N300_01899| N301_09953| N302_13782| N303_09975| N307_06819| N310_08916| N311_09342| N320_02594| N321_03385| N322_06767| N331_05591| N332_11725| N333_03696| N334_11327| N335_07624| N336_05822| N340_10303| PAL_GLEAN10024264| PANDA_004526| protein C receptor, endothelial| protein C receptor, endothelial (EPCR)| TREES_T100008643| Y1Q_008870| Y956_12532| Z169_10805| procr

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