The Function of PROCR
Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
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Protein names
Recommended name:
Endothelial protein C receptorAlternative name(s):
Activated protein C receptorAPC receptor
Endothelial cell protein C receptor
CD antigen CD201
- RS11167260 (PROCR) ??
- RS17310467 (PROCR) ??
- RS6060278 (PROCR) ??
- RS6087685 (PROCR) ??
- RS6088735 (PROCR) ??
- RS6088765 (PROCR) ??
- RS8114671 (PROCR) ??
- RS867186 (PROCR) ??
- RS9574 (PROCR) ??
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Top Gene-Substance Interactions
PROCR Interacts with These Diseases
| Disease | Score |
Substances That Increase PROCR
| Substances | Interaction | Organism | Category |
Substances That Decrease PROCR
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.
Molecular Function:
Biological Processes:
Drug Bank:
- Drotrecogin Alfa