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  3. PRLR

PRLR (Prolactin receptor)

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The Function of PRLR

This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

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Protein names

Recommended name:

Prolactin receptor

Short name:

PRL-R

PRLR SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS284737 (PRLR) ??
  2. RS76632111 (PRLR) ??

Top Gene-Substance Interactions

PRLR Interacts with These Diseases

Disease Score

Substances That Increase PRLR

Substances Interaction Organism Category

Substances That Decrease PRLR

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • CREB
  • deltaCREB
  • HNF-4alpha1
  • HNF-4alpha2
  • IRF-1

Tissue specificity:

Expressed in breast, placenta, kidney, liver and pancreas.

Gene Pathways:

  • Immune System
  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Cytokine-cytokine receptor interaction
  • Jak-STAT signaling pathway

Molecular Function:

  • Metal Ion Binding
  • Ornithine Decarboxylase Activator Activity
  • Peptide Hormone Binding
  • Prolactin Receptor Activity
  • Protein Homodimerization Activity

Biological Processes:

  • Activation Of Jak2 Kinase Activity
  • Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity
  • Cell Surface Receptor Signaling Pathway
  • Embryo Implantation
  • Jak-Stat Cascade Involved In Growth Hormone Signaling Pathway
  • Lactation
  • Negative Regulation Of Apoptotic Process
  • Steroid Biosynthetic Process
  • T Cell Activation
  • Mammary Gland Alveolus Development
  • Mammary Gland Epithelial Cell Differentiation
  • Prostate Gland Growth
  • Regulation Of Cell Adhesion
  • Regulation Of Epithelial Cell Differentiation

Drug Bank:

  • Somatropin Recombinant
  • Fluoxymesterone
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| PRL1| A306_05317| AS27_01135| AS28_06722| CB1_011123005| cPRLR| EGK_16420| equates to base 1078-1204 of D13154| H920_15533| HPRL| hPRL receptor| hPRLrI| I79_011179| lactogen receptor| MDA_GLEAN10023510| MFAB| N300_07391| N301_10898| N302_10497| N303_09107| N305_06104| N308_09857| N309_10952| N310_00147| N320_13252| N325_02863| N328_10538| N329_02031| N330_08055| N331_10941| N333_07359| N335_00184| N339_01317| oPR| PAL_GLEAN10001732| PANDA_008105| pPRLR-SF| Pr-1| Pr-3| PRL-R| prlr-a| prlr-b| PRLRb| Prlr-rs1| prolactin receptor 1| prolactin receptor b| prolactin receptor-like protein| prolactin receptor long form| prolactin receptor long isoform| prolactin receptor related sequence 1| prolactin receptor short isoform| RATPRLR| secreted prolactin binding protein| tprlr| TREES_T100020861| UY3_11070| Y1Q_011610| Y956_08754| Z169_13289| prlr

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