The Function of PRLR
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
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Protein names
Recommended name:
Prolactin receptorShort name:
PRL-R- RS284737 (PRLR) ??
- RS76632111 (PRLR) ??
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Top Gene-Substance Interactions
PRLR Interacts with These Diseases
| Disease | Score |
Substances That Increase PRLR
| Substances | Interaction | Organism | Category |
Substances That Decrease PRLR
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in breast, placenta, kidney, liver and pancreas.
Gene Pathways:
Molecular Function:
- Prolactin Receptor Activity
- Peptide Hormone Binding
- Protein Homodimerization Activity
- Ornithine Decarboxylase Activator Activity
- Metal Ion Binding
Biological Processes:
- Steroid Biosynthetic Process
- Cell Surface Receptor Signaling Pathway
- Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity
- Embryo Implantation
- Lactation
- Regulation Of Cell Adhesion
- Regulation Of Epithelial Cell Differentiation
- T Cell Activation
- Activation Of Jak2 Kinase Activity
- Negative Regulation Of Apoptotic Process
- Jak-Stat Cascade Involved In Growth Hormone Signaling Pathway
- Mammary Gland Epithelial Cell Differentiation
- Prostate Gland Growth
- Mammary Gland Alveolus Development
Drug Bank:
- Somatropin Recombinant
- Fluoxymesterone