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  3. PRKCB

PRKCB (Protein kinase C beta)

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The Function of PRKCB

Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Also involved in triglyceride homeostasis (By similarity). Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

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Protein names

Recommended name:

Protein kinase C beta type

Short name:

PKC-B

Alternative name(s):

PKC-beta

PRKCB SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS198160 (PRKCB) ??
  2. RS7404095 (PRKCB) ??
  3. RS7404928 (PRKCB) ??

Top Gene-Substance Interactions

PRKCB Interacts with These Diseases

Disease Score

Substances That Increase PRKCB

Substances Interaction Organism Category

Substances That Decrease PRKCB

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • AP-1
  • c-Jun
  • deltaCREB
  • Sp1
  • STAT1
  • STAT1beta
  • STAT1alpha
  • AML1a
  • YY1

Gene Pathways:

  • Glutamatergic synapse
  • Immune System
  • Non-small cell lung cancer
  • Neuronal System
  • Hemostasis
  • Melanogenesis
  • Pathways in cancer
  • Leishmaniasis
  • Pancreatic secretion
  • Vascular smooth muscle contraction
  • Chemokine signaling pathway
  • Leukocyte transendothelial migration
  • Endocrine and other factor-regulated calcium reabsorption
  • Calcium signaling pathway
  • Phosphatidylinositol signaling system
  • Salivary secretion
  • Gastric acid secretion
  • Long-term potentiation
  • Aldosterone-regulated sodium reabsorption
  • VEGF signaling pathway
  • Fc epsilon RI signaling pathway
  • Wnt signaling pathway
  • Amoebiasis
  • Carbohydrate digestion and absorption
  • Glioma
  • Long-term depression
  • MAPK signaling pathway
  • Signal Transduction
  • Tight junction
  • B cell receptor signaling pathway
  • Natural killer cell mediated cytotoxicity
  • African trypanosomiasis
  • GnRH signaling pathway

Enzyme Regulation:

Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-500 (activation loop of the kinase domain), Thr-642 (turn motif) and Ser-661 (hydrophobic region), need to be phosphorylated for its full activation. Specifically inhibited by enzastaurin (LY317615).

Cofactor:

Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.

Molecular Function:

  • Androgen Receptor Binding
  • Atp Binding
  • Calcium Channel Regulator Activity
  • Calcium-Dependent Protein Kinase C Activity
  • Chromatin Binding
  • Histone Binding
  • Histone Kinase Activity (H3-T6 Specific)
  • Ligand-Dependent Nuclear Receptor Transcription Coactivator Activity
  • Protein Kinase C Activity
  • Protein Kinase C Binding
  • Protein Serine/Threonine Kinase Activity
  • Zinc Ion Binding

Biological Processes:

  • Adaptive Immune Response
  • Apoptotic Process
  • B Cell Activation
  • B Cell Receptor Signaling Pathway
  • Calcium Ion Transport
  • Cellular Calcium Ion Homeostasis
  • Cellular Response To Carbohydrate Stimulus
  • Histone H3-T6 Phosphorylation
  • Intracellular Signal Transduction
  • Lipoprotein Transport
  • Mitotic Nuclear Envelope Disassembly
  • Negative Regulation Of Glucose Transport
  • Negative Regulation Of Insulin Receptor Signaling Pathway
  • Peptidyl-Serine Phosphorylation
  • Platelet Activation
  • Positive Regulation Of Angiogenesis
  • Positive Regulation Of B Cell Receptor Signaling Pathway
  • Positive Regulation Of I-Kappab Kinase/Nf-Kappab Signaling
  • Positive Regulation Of Nf-Kappab Transcription Factor Activity
  • Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
  • Protein Phosphorylation
  • Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Response To Hypoxia
  • Signal Transduction
  • Transcription, Dna-Templated

Drug Bank:

  • Tamoxifen
  • Vitamin E
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| PKC| A306_04817| AS27_12373| AS28_11622| CB1_001982006| D623_10015480| H920_05056| I79_020123| M959_10051| MDA_GLEAN10013709| N300_14213| N301_13397| N302_11732| N303_06606| N305_14957| N308_13133| PAL_GLEAN10004939| PANDA_016272| Pkcb| PKC-B| pkc-beta| PKCbeta| pkc betaII| PRKCB1| PRKCB2| prkcbb| protein kinase C, beta| protein kinase C beta 1| protein kinase C, beta 1| protein kinase C, beta 1 polypeptide| protein kinase C beta 2| protein kinase C beta I| protein kinase C beta II| protein kinase C beta-II| Protein kinase C beta type| Protein kinase C beta type-like protein| TREES_T100007609| UY3_05905| xPKCb| XPKCII| Y1Q_023762| Y956_00701| Z169_14789| prkcb

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