The Function of PRKAR2B
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
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Protein names
Recommended name:
cAMP-dependent protein kinase type II-beta regulatory subunit- RS13224682 (PRKAR2B) ??
- RS3752645 (PRKAR2B) ??
- RS7779057 (PRKAR2B) ??
- RS7798500 (PRKAR2B) ??
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Top Gene-Substance Interactions
PRKAR2B Interacts with These Diseases
| Disease | Score |
Substances That Increase PRKAR2B
| Substances | Interaction | Organism | Category |
Substances That Decrease PRKAR2B
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
Gene Pathways:
Molecular Function:
- Camp Binding
- Camp-Dependent Protein Kinase Inhibitor Activity
- Camp-Dependent Protein Kinase Regulator Activity
- Protein Kinase A Catalytic Subunit Binding
- Ubiquitin Protein Ligase Binding
Biological Processes:
- Activation Of Protein Kinase A Activity
- Blood Coagulation
- Cellular Response To Glucagon Stimulus
- Fatty Acid Metabolic Process
- G2/M Transition Of Mitotic Cell Cycle
- Intracellular Signal Transduction
- Learning
- Negative Regulation Of Camp-Dependent Protein Kinase Activity
- Renal Water Homeostasis
- Response To Antipsychotic Drug
- Response To Clozapine