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  3. PRKAR2B

PRKAR2B (Protein kinase cAMP-dependent type II regulatory subunit beta)

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The Function of PRKAR2B

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.

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Protein names

Recommended name:

cAMP-dependent protein kinase type II-beta regulatory subunit

PRKAR2B SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS13224682 (PRKAR2B) ??
  2. RS3752645 (PRKAR2B) ??
  3. RS7779057 (PRKAR2B) ??
  4. RS7798500 (PRKAR2B) ??

Top Gene-Substance Interactions

PRKAR2B Interacts with These Diseases

Disease Score

Substances That Increase PRKAR2B

Substances Interaction Organism Category

Substances That Decrease PRKAR2B

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • deltaCREB
  • C/EBPbeta
  • C/EBPalpha
  • c-Fos
  • HSF2

Tissue specificity:

Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.

Gene Pathways:

  • Metabolism
  • Disease
  • Immune System
  • Signal Transduction
  • Hemostasis
  • Apoptosis
  • Insulin signaling pathway
  • Transmembrane transport of small molecules

Molecular Function:

  • Camp Binding
  • Camp-Dependent Protein Kinase Inhibitor Activity
  • Camp-Dependent Protein Kinase Regulator Activity
  • Protein Kinase A Catalytic Subunit Binding
  • Ubiquitin Protein Ligase Binding

Biological Processes:

  • Activation Of Protein Kinase A Activity
  • Blood Coagulation
  • Cellular Response To Glucagon Stimulus
  • Fatty Acid Metabolic Process
  • G2/M Transition Of Mitotic Cell Cycle
  • Intracellular Signal Transduction
  • Learning
  • Negative Regulation Of Camp-Dependent Protein Kinase Activity
  • Renal Water Homeostasis
  • Response To Antipsychotic Drug
  • Response To Clozapine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_04847| AS27_01694| AS28_06443| cAMP-dependent protein kinase, regulatory subunit beta 2| cAMP-dependent protein kinase subunit R2 beta| cAMP-dependent protein kinase type II-beta regulatory chain| cAMP-dependent protein kinase type II-beta regulatory subunit| CB1_000803060| D623_10033917| GW7_15863| H920_09526| H_RG363E19.2| I79_020150| M959_00615| N300_00430| N301_16672| N302_06350| N303_05878| N305_14124| N306_13499| N307_10150| N308_10094| N309_11811| N311_00698| N320_07338| N321_04403| N322_03825| N325_00932| N326_01916| N327_02251| N329_11655| N330_05422| N331_11287| N335_06887| N336_00648| N340_11799| N341_01329| PAL_GLEAN10013453| PKA-R2| Pkarb2| PKARIIbeta| PRKAR2| protein kinase, cAMP-dependent, regulatory subunit type II beta| protein kinase, cAMP dependent regulatory, type II beta| protein kinase, cAMP-dependent, regulatory, type II, beta| protein kinase cAMP-dependent type 2 regulatory subunit beta| RATDNA| RII(beta)| RII-BETA| Type II beta regulatory subunit of cAMP-dependent protein kinase| UY3_11600| WUGSC:H_RG363E19.2| Y1Q_010555| Y956_10507| Z169_08002| prkar2b

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