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  3. PRKAB1

PRKAB1 (Protein kinase AMP-activated non-catalytic subunit beta 1)

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The Function of PRKAB1

Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).

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Protein names

Recommended name:

5'-AMP-activated protein kinase subunit beta-1

Alternative name(s):

AMPK subunit beta-1
AMPKb

Top Gene-Substance Interactions

PRKAB1 Interacts with These Diseases

Disease Score

Substances That Increase PRKAB1

Substances Interaction Organism Category

Substances That Decrease PRKAB1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • Nkx2-5
  • NRF-2
  • NCX/Ncx

Gene Pathways:

  • Signal Transduction
  • Adipocytokine signaling pathway
  • Insulin signaling pathway
  • Hypertrophic cardiomyopathy (HCM)
  • Membrane Trafficking
  • Translocation of Glut4 to the Plasma Membrane
  • Organelle biogenesis and maintenance

Molecular Function:

  • Amp-Activated Protein Kinase Activity

Biological Processes:

  • Cell Cycle Arrest
  • Fatty Acid Biosynthetic Process
  • Macroautophagy
  • Positive Regulation Of Gene Expression
  • Protein Heterooligomerization
  • Protein Phosphorylation
  • Regulation Of Protein Kinase Activity
  • Regulation Of Signal Transduction By P53 Class Mediator
  • Signal Transduction

Drug Bank:

  • Acetylsalicylic Acid
  • Metformin
  • Adenosine Monophosphate
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 5'-AMP-activated protein kinase subunit beta-1| 5'-AMP-activated protein kinase 40 kDa subunit| 5'AMP-activated protein kinase beta-1 non-catalytic subunit| 5'-AMP-activated protein kinase beta-1 subunit| 5-AMP-activated protein kinase beta subunit| 5'-AMP-activated protein kinase, beta subunit| 5'-AMP-activated protein kinase subunit beta-1-like protein| A306_13968| AMP-activated protein kinase beta 1 non-catalytic subunit| AMP-activated protein kinase beta subunit| AMPK| AMPK-activated protein kinase beta-1 subunit| AMPKb| AMPK beta 1| AMPK beta -1 chain| AMPK beta-1 chain| AMPK subunit beta-1| Anapl_02153| AS27_08333| AS28_08556| E430008F22| EGK_04249| EH28_00793| H920_14984| HAMPKb| M91_16450| M959_05999| N300_08278| N301_16437| N306_12534| N307_00990| N308_10063| N309_09590| N310_11128| N312_11642| N320_13042| N321_01871| N325_00102| N328_02597| N329_09476| N330_05464| N331_09318| N332_04782| N333_12045| N334_05912| N336_03570| N339_01173| N340_00632| N341_03753| PAL_GLEAN10010766| PANDA_008368| protein kinase, AMP-activated, beta 1 non-catalytic subunit| protein kinase, AMP-activated, noncatalytic, beta-1| TREES_T100018630| UY3_18494| Y1Q_004029| Y956_15789| Z169_14586| prkab1

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