The Function of PRKAB1
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
Protein names
Recommended name:
5'-AMP-activated protein kinase subunit beta-1Alternative name(s):
AMPK subunit beta-1AMPKb
Top Gene-Substance Interactions
PRKAB1 Interacts with These Diseases
| Disease | Score |
Substances That Increase PRKAB1
| Substances | Interaction | Organism | Category |
Substances That Decrease PRKAB1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Protein Phosphorylation
- Fatty Acid Biosynthetic Process
- Cell Cycle Arrest
- Signal Transduction
- Positive Regulation Of Gene Expression
- Macroautophagy
- Regulation Of Protein Kinase Activity
- Protein Heterooligomerization
- Regulation Of Signal Transduction By P53 Class Mediator
Drug Bank:
- Acetylsalicylic Acid
- Metformin
- Adenosine Monophosphate