The Function of PRDX5
Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.
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Protein names
Recommended name:
Peroxiredoxin-5, mitochondrialShort name:
PLPAlternative name(s):
Alu corepressor 1Antioxidant enzyme B166
AOEB166
Liver tissue 2D-page spot 71B
Peroxiredoxin V
Prx-V
Peroxisomal antioxidant enzyme
TPx type VI
Thioredoxin peroxidase PMP20
Thioredoxin reductase
Top Gene-Substance Interactions
PRDX5 Interacts with These Diseases
| Disease | Score |
Substances That Increase PRDX5
| Substances | Interaction | Organism | Category |
Substances That Decrease PRDX5
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed.
Gene Pathways:
Molecular Function:
- Rna Polymerase Iii Regulatory Region Dna Binding
- Peroxidase Activity
- Receptor Binding
- Thioredoxin Peroxidase Activity
- Antioxidant Activity
- Cysteine-Type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
- Protein Dimerization Activity
- Peroxiredoxin Activity
- Peroxynitrite Reductase Activity
Biological Processes:
- Response To Reactive Oxygen Species
- Inflammatory Response
- Response To Oxidative Stress
- Negative Regulation Of Transcription From Rna Polymerase Iii Promoter
- Positive Regulation Of Collagen Biosynthetic Process
- Cellular Response To Reactive Oxygen Species
- Hydrogen Peroxide Catabolic Process
- Negative Regulation Of Apoptotic Process
- Cell Redox Homeostasis
- Negative Regulation Of Oxidoreductase Activity
- Regulation Of Apoptosis Involved In Tissue Homeostasis
- Nadph Oxidation
- Reactive Nitrogen Species Metabolic Process