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  3. PRDX5

PRDX5 (Peroxiredoxin 5)

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The Function of PRDX5

Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.

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Protein names

Recommended name:

Peroxiredoxin-5, mitochondrial

Short name:

PLP

Alternative name(s):

Alu corepressor 1
Antioxidant enzyme B166
AOEB166
Liver tissue 2D-page spot 71B
Peroxiredoxin V
Prx-V
Peroxisomal antioxidant enzyme
TPx type VI
Thioredoxin peroxidase PMP20
Thioredoxin reductase

Top Gene-Substance Interactions

PRDX5 Interacts with These Diseases

Disease Score

Substances That Increase PRDX5

Substances Interaction Organism Category

Substances That Decrease PRDX5

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • AP-1
  • AhR
  • deltaCREB
  • HNF-4alpha1
  • HNF-4alpha2
  • STAT1
  • STAT1beta
  • STAT1alpha
  • Sox9

Tissue specificity:

Widely expressed.

Gene Pathways:

  • Peroxisome
  • Cellular responses to stress

Molecular Function:

  • Antioxidant Activity
  • Cysteine-Type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
  • Peroxidase Activity
  • Peroxiredoxin Activity
  • Peroxynitrite Reductase Activity
  • Protein Dimerization Activity
  • Receptor Binding
  • Rna Polymerase Iii Regulatory Region Dna Binding
  • Thioredoxin Peroxidase Activity

Biological Processes:

  • Cell Redox Homeostasis
  • Cellular Response To Reactive Oxygen Species
  • Hydrogen Peroxide Catabolic Process
  • Inflammatory Response
  • Nadph Oxidation
  • Negative Regulation Of Apoptotic Process
  • Negative Regulation Of Oxidoreductase Activity
  • Negative Regulation Of Transcription From Rna Polymerase Iii Promoter
  • Positive Regulation Of Collagen Biosynthetic Process
  • Reactive Nitrogen Species Metabolic Process
  • Regulation Of Apoptosis Involved In Tissue Homeostasis
  • Response To Oxidative Stress
  • Response To Reactive Oxygen Species

Drug Bank:

  • Benzoic Acid
  • Auranofin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| PLP| acr1| Alu co-repressor 1| antioxidant enzyme B166| aoeb166| AOPP| B166| CB1_000996002| EH28_17460| epididymis secretory protein Li 55| GW7_20669| HEL-S-55| liver tissue 2D-page spot 2D-0014IV| liver tissue 2D-page spot 71B| MDA_GLEAN10017951| PAL_GLEAN10011419| PANDA_004844| Peroxiredoxin-5, mitochondrial| peroxiredoxin 6| peroxiredoxin V| peroxiredoxin V (PrxV) protein| peroxisomal antioxidant enzyme| peroxisomal membrane protein 20| pmp20| Prdx6| prx5| prx-5| prx-V| Prx V| PRXV| SBBI10| thioredoxin peroxidase PMP20| thioredoxin reductase| TPx type VI| TREES_T100019389| prdx5

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