The Function of PRCP
Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH.
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Protein names
Recommended name:
Lysosomal Pro-X carboxypeptidaseShort name:
PRCPAlternative name(s):
Angiotensinase CLysosomal carboxypeptidase C
Proline carboxypeptidase
Prolylcarboxypeptidase
- RS2298668 (PRCP) ??
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Top Gene-Substance Interactions
Substances That Increase PRCP
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Substances That Decrease PRCP
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highest levels in placenta, lung and liver. Also present in heart, brain, pancreas and kidney.
Molecular Function:
Biological Processes:
- Regulation Of Thyroid Hormone Mediated Signaling Pathway
- Plasma Kallikrein-Kinin Cascade
- Negative Regulation Of Systemic Arterial Blood Pressure
- Blood Coagulation, Intrinsic Pathway
- Glucose Homeostasis
- Regulation Of Blood Vessel Endothelial Cell Migration
- Angiogenesis Involved In Wound Healing
- Energy Homeostasis
- Regulation Of Reactive Oxygen Species Metabolic Process